The trajectories and clinical experiences of ICD therapy (tracer-ICD) study

Active Project Grant Awarded Last action

Award ID
R01AG068141
Recipient
Awarding agency
Obligated
$8,203,071

Award facts

Assistance listing
93.866 Aging Research
Completion date 93% complete
Originally
Funding
  • $7,435,984.00 Federal
  • $767,087.00 Non-federal
Place of performance
Boston, MA 02215, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
X over 50,000 implantable cardioverter-defibrillators (icds) are implanted annually in patients =65 years old at an estimated cost of >$2 billion. ICD guidelines draw upon trials enrolling few older patients, yet half of these patients will either be dead or enrolled in hospice within 5 years of implantation. Though medicare now mandates shared decision-making (SDM) for icds, few studies have investigated questions vital for older patients, including health status trajectories and quality of life. Improved SDM for older patients requires moving beyond average treatment effect estimates to incorporate precision modeling of these outcomes. There is therefore a pressing need for longitudinal data to support patient-centered SDM for older adults. To extend our prior work and further improve SDM for older adults considering an ICD, we propose the trajectories and clinical experiences of ICD therapy (tracer-ICD) study, a multi-center prospective cohort with the goal of better defining patient-centered goals and experiences in older patients undergoing ICD implantation. We will prospectively collect data on geriatric conditions and quality of life from patients at 5 sites, enriched with remote monitoring data on arrhythmias and physical activity, to evaluate their clinical and functional trajectories (aim 1). This cohort will support further refinement of our statistical model to personalize prediction of treatment outcomes (aim 2). Lastly, we will use mixed methods to identify optimal implementation strategies for translating these individualized prediction profiles into SDM for icds (aim 3).this proposal is led by an early stage investigator whose expertise in cardiac electrophysiology, geriatric medicine, and outcomes research will be complemented by an experienced research team with a strong record of collaboration. Impact: as the first comprehensive, prospective study of older ICD patients, tracer-ICD will generate unique patient-centered and personalized data essential for characterizing outcomes of this common procedure in a vulnerable population. Much like other large cohort studies in older persons, we anticipate the robust data emerging from tracer-ICD will serve as a rich resource that will improve care for millions of patients considering ICD implantation, and provide essential, evidence-based guidance for translating personalized outcome profiling into the SDM experience.

Transactions

Action Federal Non-federal Date
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Amendment $712,025 $0
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Subawards

Subrecipient Amount Awarded
President And Fellows Of Harvard College Dr. Haneuse will work with Dr. Kramer to advise/collaborate on all aspects related to the design of data collection and to perform the statistical analyses. The… $111,445
Providence Health & Services-Oregon The TRAjectories and Clinical ExpeRiences of ICD Therapy (TRACER-ICD) Study is a prospective study of patients scheduled for placement of implantable… $31,274
Saint Luke's Hospital Of Kansas City The TRAjectories and Clinical ExpeRiences of ICD Therapy (TRACER-ICD) Study Coordinating Center: Beth Israel Deaconess Medical Center Principal Investigator:… $137,776
Saint Luke's Hospital Of Kansas City STATEMENT OF WORK – Saint Luke’s Hospital of Kansas City The TRAjectories and Clinical ExpeRiences of ICD Therapy (TRACER-ICD) Study… $275,762
Mayo Clinic The TRAjectories and Clinical ExpeRiences of ICD Therapy (TRACER-ICD) Study Coordinating Center: Beth Israel Deaconess Medical Center Principal Investigator:… $172,431
The Regents Of The University Of Colorado The TRAjectories and Clinical ExpeRiences of ICD Therapy (TRACER-ICD) Study is a prospective study of patients scheduled for placement of implantable… $373,102
The Trustees Of The University Of Pennsylvania The TRAjectories and Clinical ExpeRiences of ICD Therapy (TRACER-ICD) Study Coordinating Center: Beth Israel Deaconess Medical Center Principal Investigator:… $254,543
Emory University TRAjectories and Clinical ExpeRiences of ICD Therapy (TRACER-ICD) Study Principal investigator (PI): Dan Kramer, MD Coordinating center: Beth Israel Deaconess… $217,030
Hebrew Rehabilitation Center Dae Kim, MD, MPH, ScD, is a board-certified geriatrician and clinical investigator with expertise in the measurements and analyses of frailty and functional… $64,897

Quick answers

Who received award R01AG068141?

R01AG068141 was awarded to Beth Israel Deaconess Medical Center, Inc. by National Institute on Aging (National Institutes of Health) on April 15, 2021.

How much is award R01AG068141 worth?

$8,203,071 has been obligated on R01AG068141: $7,435,984 in federal funding and $767,087 in non-federal funding.

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