Project Grant R01AA033087
- The National Institute on Alcohol Abuse and Alcoholism awarded Trustees of Boston University $580,556 on May 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate the role of pituitary adenylate cyclase activating polypeptide (PACAP) in heavy alcohol drinking and associated anxiety-like behavior. The recipient will conduct mechanistic research using animal models of heavy alcohol drinking combined with pharmacological, molecular, and viral approaches to test whether the...
- The National Institute on Alcohol Abuse and Alcoholism awarded Yale University $100,228 under the Alcohol Research Programs (CFDA 93.273) on October 27, 2026, to investigate the neurobiological mechanisms underlying the co-occurrence of alcohol use disorder and post-traumatic stress disorder. The project examines how stress exposure disrupts excitation-inhibition balance in the medial prefrontal cortex, driving increased alcohol consumption and heightened motivation for alcohol use. Using single...
- The National Institute on Alcohol Abuse and Alcoholism awarded the University of Massachusetts $416,315 on August 1, 2026, under the Alcohol Research Programs (CFDA 93.273) to identify neural circuit functional plasticity underlying hedonic tolerance to alcohol and other rewards in a rat model of chronic alcohol exposure. The research characterizes how chronic intermittent ethanol exposure affects behavioral measures of hedonic tolerance for both alcohol and non-alcohol rewards, measuring...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Washington University $555,331 on August 13, 2026, under the Alcohol Research Programs (CFDA 93.273) to examine the metabolic-epigenetic regulation of alcohol intake and associated molecular mechanisms. The funded research explores how alcohol-derived acetate generated during alcohol metabolism affects brain histone acetylation and subsequently influences alcohol intake behavior. The project builds on preliminary findings...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Medical University of South Carolina $149,190 on March 9, 2026, under the Alcohol Research Programs (CFDA 93.273) to explore the role of medial prefrontal cortex corticotropin-releasing factor circuitry in stress-enhanced alcohol consumption. The research examines how chronic alcohol exposure and chronic stress alter corticotropin-releasing factor (CRF) and CRF receptor 1 (CRFR1) neurons in the prelimbic cortex, a key brain...
- The National Institute on Alcohol Abuse and Alcoholism awarded Texas A&M University System Health Science Center $635,002 on June 15, 2026, under the Alcohol Research Programs (CFDA 93.273) to investigate cholinergic modulation of striatal circuits in alcohol use disorder. The project examines how chronic alcohol intake affects acetylcholine signaling in the dorsomedial striatum, focusing on the interaction between direct-pathway medium spiny neurons and cholinergic interneurons. Research...
- The National Institute on Alcohol Abuse and Alcoholism awarded The Ohio State University $1,771,875 under the Alcohol Research Programs (CFDA 93.273) on August 4, 2026, for research into the novel mechanism of nuclear histone deacetylase 4 (HDAC4) in early-life stress-induced alcohol consumption, preference, and tolerance in offspring. The research develops a mouse model using offspring born to dams that experienced prenatal restraint stress during pregnancy to investigate how early-life...
- The National Institute on Alcohol Abuse and Alcoholism awarded Yale University $880,688 on August 4, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct research imaging glucocorticoid function in women with childhood trauma and alcohol use disorder. The research uses positron emission tomography with a novel radiotracer called [18F]FMOZAT to investigate brain cortisol as a potential biomarker of stress dysregulation in women with childhood trauma and alcohol use disorder. The...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded $167,500 in Project Grant funding to the University of Massachusetts Medical School on September 17, 2025, through the Alcohol Research Programs (CFDA 93.273) for a research study investigating sex differences in excessive alcohol use patterns across young adulthood and middle age. The research will utilize longitudinal data from the National Longitudinal Study of Adolescent to Adult Health (Add Health) to examine how...
- The National Institute on Alcohol Abuse and Alcoholism awarded Yale University $713,580 on August 6, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct imaging research on sex differences in the cortical reward system of people with alcohol use disorder. The research examines dopamine neurotransmission in the mesocortical pathway—which regulates executive functions, reward sensitivity, stress response, and cognitive function—comparing men and women with alcohol use disorder....
The National Institute on Alcohol Abuse and Alcoholism awarded Trustees of Tufts College $686,774 on July 20, 2026, under the Alcohol Research Programs (CFDA 93.273) to conduct behavioral neurobiology research on stress, alcohol responsivity, and alcohol drinking patterns. The research uses rodent models to investigate how stress exposure alters sensitivity to alcohol's aversive effects and the neural circuits involved. The study employs classical and operant conditioning paradigms combined with chemogenetics, fiber photometry, and immunohistochemistry to determine the role of the lateral hypothalamus to lateral habenula glutamatergic circuit in alcohol aversion, assess its contribution to alcohol self-administration, and elucidate stress-related changes in behavioral and neural responsivity to alcohol. The project addresses alcohol use disorder as a major public health concern that imposes a $249 billion annual economic burden and contributes to over 178,000 deaths per year in the United States, with stress identified as a key driver of problematic drinking, particularly in individuals who cope through avoidance of stress-associated stimuli. The period of performance runs through March 31, 2031. Work is performed in Boston, Massachusetts. The award is structured as a Project Grant, providing support for a specified project period with possible renewal as a competing request.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $686.8k | 7/22/26 |