This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), provides $688,199 to Yale University to conduct research on the role of non-parenchymal cells in driving the key features of alcohol-associated hepatitis (AAH) in a fully humanized mouse liver model. The study aims to examine specific ligand-receptor interactions between non-parenchymal cells and human hepatocytes that may be responsible for...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $537,587 Project Grant under the Alcohol Research Programs (CFDA 93.273) to The University of Texas Southwestern Medical Center to conduct research on the metabolic consequences of liver inflammation on alcohol consumption and alcohol-associated liver disease (ALD). The key objectives are to identify the mechanisms by which the transcription factor IRF3 suppresses the expression and secretion of the metabolic regulator...
This federal Project Grant award, valued at $523,477.00 and awarded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) on September 25, 2024, supports research to study alcohol-associated liver disease (ALD) and its interaction with the rs738409 variant in the PNPLA3 gene. The key products and services to be delivered under this grant include: Developing a human induced pluripotent stem cell (hiPSC)-derived in vitro liver culture...
This Project Grant award, totaling $179,154, was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to the University of Colorado-Denver. The award will support research to elucidate the role of Wnt signaling pathways in the activation of hepatic stellate cells and the development of alcohol-related liver fibrosis. Specifically, the project aims to determine if canonical Wnt ligands promote the transdifferentiation of...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $438,375 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Cedars-Sinai Medical Center to establish a human liver-on-a-chip model for studying alcohol-associated liver disease (ALD). The 2-year project, starting September 2023, aims to investigate the roles of liver sinusoidal endothelial cells and acetaldehyde metabolism in regulating ethanol-induced liver damage as well as the contribution of fibrotic...
This $442,898 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support research to define the contributions of macrophage migration inhibitory factor (MIF) and its receptor CD74 in alcohol-associated liver disease (ALD). The research plan includes three specific aims: 1) characterizing the role of CD74 expression in hepatocytes and myeloid cells during and after ethanol feeding in mice, 2) resolving the...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will support the development and testing of a novel in vivo model called CHIMERA-BONCAT. This model will enable comprehensive, unbiased, and cell-type-specific characterization of the human microglial response to alcohol exposure. The $214,385 award, with a period of performance from August 2024 to July 2026, will fund research...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will support the development of novel 3D human brain circuits to investigate the role of microglia in alcohol use disorder (AUD) and Alzheimer's disease (AD) pathology. The $223,531 award to the University of North Carolina at Chapel Hill will fund research to elucidate how alcohol-induced changes in microglial metabolism...
The University of California, San Diego (UCSD) was awarded a $414,750 Project Grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to investigate the role of intestinal gp130 signaling in preventing alcohol-associated liver disease. The proposed research aims to define the gp130-STAT3-Reg3 signaling axis involved in protecting against ethanol-induced liver disease and assess the potential of a novel engineered gp130...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the federal Alcohol Research Programs (CFDA 93.273), provides $1,158,934.00 to the University of Kansas Medical Center Research Institute, Inc. over a period from August 20, 2024 to May 31, 2029. The project aims to investigate the mechanisms by which chronic alcohol exposure leads to the formation of dysfunctional megamitochondria in the liver, and how this contributes to alcohol-associated liver...