The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $119,600 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) with a performance period from July 2024 to July 2027. The grant funds research to identify and understand the mechanisms by which aging and alcohol consumption cooperatively contribute to the development of alcohol-associated liver disease (ALD). The project aims to...
This Project Grant award, valued at $1,158,934.00, was issued on August 20, 2024 by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program. The award supports research to understand the mechanisms of mitochondrial dynamics, quality control, and mitochondrial DNA-mediated inflammation in alcohol-associated liver disease. The University of Kansas Medical Center Research Institute, Inc. (KUMCRI) is the prime recipient...
This federal Project Grant award in the amount of $523,477.00 was issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) grant program. The award supports a research project focused on studying alcohol-associated liver disease (ALD) and its interaction with the rs738409 variant in the PNPLA3 gene using a human induced pluripotent stem cell (hiPSC)-derived liver culture model. The key objectives are to: 1) investigate the role of...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will fund research to define the contributions of the MIF-CD74 signaling pathway in alcohol-associated liver disease (ALD). The $442,898 grant, awarded on September 1, 2024, will support a 5-year research plan at the University of Texas Health Science Center at Houston to: 1) characterize the role of CD74 expression in hepatocytes and myeloid...
This $537,587 federal Project Grant award, provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), supports research to identify the mechanisms by which the interferon regulatory factor 3 (IRF3) suppresses the expression and secretion of fibroblast growth factor 21 (FGF21) in the liver, and to understand the impact of this regulatory axis on alcohol consumption and alcohol-associated liver disease (ALD). The grant, which...
The University of Kansas Medical Center Research Institute, Inc. (KUMCRI) received a $406,852 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273). The grant supports research to understand the molecular mechanisms by which alcohol decreases VMP1 (vacuole membrane protein 1) in pancreatic acinar cells, and how VMP1-mediated autophagy (ER-phagy) protects against alcohol-induced pancreatitis. The goal is to...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the CFDA 93.273 Alcohol Research Programs, provides funding to The Administrators of Tulane Educational Fund (Tulane University) to investigate the role of the TET1 enzyme and sex differences in alcohol-associated liver disease and hepatocellular carcinoma development. The $477,626 award, which runs from May 2, 2025, to April 30, 2030, aims to determine the impact of female sex and reduced...
The federal Project Grant award R01AA031670, sponsored by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), supports research to investigate the role of hepatic stellate cells (HSCs) in the progression of alcohol-associated hepatitis (AH). The primary awardee, the University of Southern California (USC), will conduct studies to determine how the transcription factors CYP1B1, PRRX1, and NR4A2 regulate the development of a specific...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support research to examine the role of non-parenchymal cells in driving the key features of alcohol-associated hepatitis (AAH) in a fully humanized mouse liver model. The $688,199 award to Yale University will fund a 5-year research project (June 1, 2025 - February 28, 2030) that aims to investigate the species-specific paracrine...
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $438,375 Project Grant under the Alcohol Research Programs (CFDA 93.273) to Cedars-Sinai Medical Center to establish a human liver-on-a-chip model for studying alcohol-associated liver disease (ALD). The 2-year project, starting September 2023, aims to investigate the roles of liver sinusoidal endothelial cells and acetaldehyde metabolism in regulating ethanol-induced liver damage as well as the contribution of fibrotic...