This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $1,123,357.00 to support research on the bone marrow microenvironment and its role in regulating blood cell production. The research, to be conducted by the Children's Hospital Medical Center in Cincinnati, Ohio, aims to define the spatial organization and specialized vascular microenvironments within the bone marrow that recruit and...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $792,498 to the Trustees of Indiana University, Indianapolis (IU Indianapolis) to conduct research on hematopoietic stem cells (HSCs) and their regulation under low oxygen tension (hypoxia). The primary goals are to: 1) understand how hypoxia activates the transcription factor TFE3 to facilitate HSC self-renewal, 2) determine...
This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $159,512 to generate a comprehensive single-cell transcriptomic and epigenomic map of human bone marrow cells and experimentally establish the mesenchymal hierarchy in human bone. The primary goals are to unravel the complex cellular signaling networks in bone marrow and provide insights into how cell fates are regulated, with the long-term aim of developing novel...
This Project Grant award from the National Heart Lung and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $734,607 to Boston Medical Center Corporation (BMC) to elucidate the key endothelial mechanisms that facilitate the trans-endothelial migration of hematopoietic stem cells (HSCs) into their bone marrow niches. The 5-year project aims to define the endothelial receptor domains, binding partners, and vascular endocytosis/membrane...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $146,876 to the Coriell Institute for Medical Research to develop new methods for expanding functional hematopoietic stem cells (HSCs) from cryopreserved umbilical cord blood (UCB) samples. The project aims to optimize an approach using PPAR-α agonists, which have been shown to significantly expand long-term functional UCB HSCs...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $169,156 to The Washington University in St. Louis to support a 5-year research program focused on optimizing hematopoietic stem cell transplantation (HSCT) to treat non-malignant diseases, particularly sickle cell disease (SCD). The key objectives are to: 1) Evaluate novel stem cell mobilization regimens combining VLA-4 and CXCR4 inhibition to generate...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $802,301 Project Grant under CFDA 93.837 - Cardiovascular Diseases Research to Weill Medical College of Cornell University. The grant's objective is to define the mechanisms that control the stem cell niche, with the aim of inhibiting the expansion of mutated blood stem cells that can lead to increased risk of life-shortening conditions like strokes, heart disease, and blood cancers. The research will identify the signals that...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $773,257 to St. Jude Children's Research Hospital Inc. to investigate the mechanisms of lysosome segregation and cell fate regulation in dividing hematopoietic stem cells (HSCs). The research aims to identify factors regulating lysosome segregation during HSC division and how this process influences HSC self-renewal and...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the Cardiovascular Diseases Research federal grant program (CFDA 93.837), aims to evaluate methods for improving the homing and engraftment efficiency of CD34+ cells from sickle cell disease (SCD) patients. The $128,100 award to the New York Blood Center, Inc. will support research to determine if co-infusing the CD34+ cells with their flow-through accessory cells, normally discarded after CD34+ cell...
This $677,600 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to gain a mechanistic understanding of erythroid progenitor (EP) self-renewal, both in vitro and in vivo. The primary goals are to: Test the hypothesis that the BMI1/RING1B chromatin modulators regulate human self-renewing erythroblast (SRE) self-renewal through epigenetic control of transcription and cholesterol homeostasis. Test the hypothesis that...