Project Grant R00HL177827

Award Date 7/15/25
Completion Date 6/30/28
Dollars Obligated $445K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Pensilvania, EE. UU.
Similar Awards
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $445,000.00 to The Children's Hospital of Philadelphia (CHOP) to develop technologies for delineating haplotype-resolved, full-length transcriptomes in bulk tissues and single cells. The project aims to characterize transcript isoforms of haploinsufficient genes to discover novel therapeutic targets, as well as establish a program for...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $1,123,357.00 to support research on the bone marrow microenvironment and its role in regulating blood cell production. The research, to be conducted by the Children's Hospital Medical Center in Cincinnati, Ohio, aims to define the spatial organization and specialized vascular microenvironments within the bone marrow that recruit and...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $657,308 to The Children's Hospital of Philadelphia (CHOP) to conduct research on the CXCL12 signaling axis and its role in pulmonary arterial heterogeneity, development, and disease. The key objectives of this 12-month project are to: 1) define the spatiotemporal role of CXCL12 signaling in pulmonary vascular development, 2)...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $153,117 to support a 5-year research project focused on improving hematopoietic stem cell (HSPC) transplantation outcomes. The goal is to investigate mechanisms of HSPC-niche cell crosstalk, specifically how HSPC-derived extracellular vesicles promote remodeling of bone marrow endothelial cells and migration of HSPCs. The...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $445,000 to The Children's Hospital of Philadelphia to conduct research on the role of neutrophil extracellular traps (NETs) in thromboinflammatory diseases. The research aims to: 1) characterize the role of NETs in immune homeostasis, 2) define the mechanism by which platelet factor 4 (PF4) and an Fc-modified anti-PF4 antibody...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $694,754 to The Washington University in St. Louis to conduct research on understanding the molecular and cellular mechanisms underlying cardiomyopathies and identifying potential therapeutic interventions. The key objectives are to: 1) determine if patient mutations in the troponin gene can be grouped based on common molecular...
This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $445,000 in funding to The Children's Hospital of Philadelphia to study the mechanisms by which impaired mitochondrial function leads to failure of neutrophil development, and how neutrophil precursors use somatic mutations to adapt to this cell-intrinsic stress. The goal is to define the pathophysiology of severe congenital neutropenia caused by CLPB mutations...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under CFDA 93.837 - Cardiovascular Diseases Research provides $623,874 to uncover novel regulatory pathways and functions of the telomerase RNA component (TERC) in the hematopoietic system. The research aims to identify regulators of TERC decay and its direct functions outside of telomere length regulation, which could explain the disproportionate role of TERC mutations in bone marrow failure. The...
This federal Project Grant award of $2,249,307, provided by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), aims to study the premature maturation arrest of pluripotent-derived cardiomyocytes (PSC-CMs) and develop strategies to overcome this issue. The project will leverage a high-resolution single cell transcriptome map of endogenous cardiomyocyte maturation to identify a critical gene regulatory network underlying the maturation failure in PSC-CMs....
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $792,498 to the Trustees of Indiana University, Indianapolis (IU Indianapolis) to conduct research on hematopoietic stem cells (HSCs) and their regulation under low oxygen tension (hypoxia). The primary goals are to: 1) understand how hypoxia activates the transcription factor TFE3 to facilitate HSC self-renewal, 2) determine...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under CFDA Program 93.837 - Cardiovascular Diseases Research, is providing $445,000.00 to The Children's Hospital of Philadelphia (CHOP) over the period of July 15, 2025 to June 30, 2028.

The funding supports research to determine the molecular mechanisms by which the Tropomyosin 1 gene product regulates the TNF-alpha signaling pathway in hematopoietic stem and progenitor cells and their hemogenic endothelial precursors. This work aims to understand how Tropomyosin 1 deficiency can enhance the in vitro production of transplantable hematopoietic stem and progenitor cells, which has implications for advancing cell-based therapies and regenerative medicine applications. The research leverages CHOP's expertise in hematopoiesis, human genetics, bioinformatics, and induced pluripotent stem cell technologies.

Generated 8/5/25, 2:47 AM