Project Grant R00HL171844
- Federal Grant Award Summary The University of Utah received a $183,600 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 19, 2025, with completion by August 31, 2027. The award funds research investigating metabolite transport modulation to mitigate myocardial ischemic-reperfusion (I/R) injury, a cardiac injury mechanism that occurs during standard heart attack treatment protocols...
- Federal Grant Award Summary The University of Utah received a $654,530 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025 through July 31, 2029. This research project investigates the role of serum glucocorticoid kinase 1 (SGK1) in cardiometabolic heart failure with preserved ejection fraction (HFPEF), addressing a critical unmet medical need affecting approximately 33 million...
- Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $745,663 to the University of Utah under the Cardiovascular Diseases Research program (CFDA 93.837) for a project grant effective September 1, 2025, through June 30, 2029. The project, "Novel Roles for IRE1 in Regulating Cardiac Fibrosis," investigates mechanistic contributions of the unfolded protein response (UPR)—specifically the IRE1 (inositol-requiring enzyme 1) pathway—in regulating cardiac...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Utah $635,681 in Project Grant funding under the Cardiovascular Diseases Research program (CFDA 93.837) on June 20, 2026, to support investigative research on the pyruvate-lactate metabolic axis in heart failure and myocardial recovery through February 28, 2030. The research deliverables include quantification of pyruvate-lactate metabolism in human heart failure and cardiac...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Utah a Project Grant totaling $740,709 under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, with completion targeted for May 31, 2029. This research initiative focuses on defining cellular and molecular mechanisms by which early-life viral-induced inflammation drives asthma susceptibility through the reprogramming of type 2 innate lymphoid cells...
- Federal Grant Award Summary The University of Utah received a $470,606 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective May 1, 2026 through January 31, 2031. The award supports research to elucidate the molecular mechanisms of smoking-induced endothelial dysfunction associated with the ALDH22 genetic variant, which affects approximately 540 million individuals globally. The project will...
- Federal Project Grant Award Summary The University of Utah received a $730,993 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 1, 2025, through May 31, 2030. This research project investigates the mechanistic contribution of internal circadian misalignment to cardiometabolic risk associated with sleep loss. The research addresses a significant public health challenge, as over...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Utah a $524,179 Project Grant (CFDA 93.837 – Cardiovascular Diseases Research) on September 5, 2025, to support research integrating multi-omics data to understand the heterogeneity of preeclampsia (PE) and long-term postpartum hypertension. The project will conduct a comprehensive analysis of whole genome sequencing (WGS) data from the NUMOM2B-HHS (Nulliparous Pregnancy Outcomes...
- Federal Project Grant Award Summary The University of Utah received $1,212,911 in funding from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) for a project investigating red meat-associated xenosialitis in atherosclerosis. The award, initiated July 1, 2026, and scheduled for completion December 31, 2027, supports research examining the human-specific pathways linking red meat consumption to atherosclerosis development. The...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $782,289 to the University of Utah under the Cardiovascular Diseases Research program (CFDA 93.837) on August 15, 2025, for a project extending through May 31, 2029. This Project Grant supports research to develop and validate machine learning (ML) models that incorporate donor lung computed tomography (CT) imaging data to predict severe primary graft dysfunction (PGD)—acute lung injury occurring within...
The University of Utah's Office of Sponsored Projects received a $249K Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) effective September 1, 2026, with completion targeted for August 31, 2029. The award funds investigative research into WNK1 (with-no lysine 1)-dependent macropinocytosis and its role in regulating myeloid progenitor cell fate during emergency hematopoiesis. The research addresses a critical gap in understanding how myeloid cells shift lineage commitment from monocyte/macrophage production toward emergency neutropoiesis in response to infection, with particular focus on the chloride-sensing kinase WNK1, macrophage-colony stimulating factor signaling, and the transcription factor interferon regulatory factor 8. The funded work delivers mechanistic research products including molecular and cellular investigations into hematopoietic pathways, with potential applications to understanding systemic inflammation, septic shock responses, and aberrant immune cell production. As a comprehensive research university, the University of Utah operates as the prime recipient and will conduct the investigation at its Salt Lake City campus, contributing to NHLBI's broader portfolio of basic and translational cardiovascular and hematologic science research.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 7/16/26 |