Project Grant R00HL169742
- This federal Project Grant award, totaling $249,000.00, was provided by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to The University of Texas Southwestern Medical Center in Dallas, TX. The grant supports research to better understand the molecular determinants of atrial fibrillation (AF), a common and serious heart rhythm disorder. The research aims to investigate how the transcription factor TBX5 and the chromatin remodeling protein CHD4...
- This Project Grant award of $231,000.00 was provided by the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), to study the functional impact of atrial myosin mutations associated with familial atrial arrhythmia. The research aims to comprehensively analyze the effects of known genetic mutations in the a-cardiac myosin heavy chain, essential light chain, and regulatory light chain on myosin activity and sarcomere...
- This federal Project Grant award of $118,632 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research by Children's Hospital Medical Center in Cincinnati, Ohio to investigate the role of matrifibrocytes in the progression of myxomatous heart valve disease. The research aims to study how stress and collagen overproduction in Marfan syndrome mitral valves induces matrifibrocytes, leading to a compensatory fibrotic response mediated by...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $673,598 to Baylor College of Medicine to conduct research on the role of cardiomyocyte-fibroblast signaling in atrial fibrillation (AF). The goal is to investigate how reduced production of the paracrine signaling molecule calcitonin, miR-31-dependent downregulation of the calcitonin receptor, and activated BMP1 signaling promote atrial remodeling, fibrosis, and AF...
- This federal Project Grant award of $174,528, awarded by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), aims to identify novel treatment targets for atrial myopathy, a condition that contributes to atrial fibrillation and associated heart failure, stroke, and mortality. The primary objective is to leverage human cohort data to discover circulating proteins and metabolites linked to both left atrial function and atrial myopathy, using...
- The National Institutes of Health's National Heart, Lung, and Blood Institute awarded a $464,502 project grant to Tarleton State University under the Cardiovascular Diseases Research program (CFDA 93.837). The grant, awarded on September 1, 2025, will fund the development of an interactive computer model of the left atrium's electrophysiology to study the underlying mechanisms leading to atrial fibrillation. Key objectives include: 1) constructing an anatomically accurate 3D model of the left...
- This $125,703 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research investigating the role of the SYNE1-giant gene in atrial cardiomyopathy. The principal investigator is conducting a comprehensive study to understand the mechanisms by which mutations in the SYNE1 gene, which encodes mechanosensitive proteins in the nuclear envelope, contribute to the development of atrial fibrillation and sinus node dysfunction....
- This federal Project Grant award, valued at $752,618, was provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Baylor College of Medicine. The grant supports a research project focused on understanding the role of inflammation in postoperative atrial fibrillation (POAF), a common complication of cardiothoracic surgery. The research aims to investigate the molecular drivers of POAF, including the involvement of infiltrating macrophages,...
- This federal Project Grant award for $769,761 from the National Heart Lung and Blood Institute, under the Cardiovascular Diseases Research program (CFDA 93.837), supports research into the mechanisms by which obesity leads to atrial fibrillation. The awardee, Weill Medical College of Cornell University, is developing a mouse model of obesity-induced atrial fibrillation to investigate how nicotinamide adenine dinucleotide (NAD+) pathways and the ATF6 endoplasmic reticulum stress pathway...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $361,083 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the Children's Hospital Medical Center in Cincinnati, OH. The grant supports research on how acetylation regulates the subcellular localization of the transcription factor YAP and its role in cardiac regeneration. The 5-year project aims to investigate how metabolic stresses affect YAP acetylation through the NAD+/SIRT1/2 axis, and whether...
This federal Project Grant award for $249,000 was provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) to Children's Hospital Medical Center in Cincinnati, Ohio. The grant supports research on the role of the PITX2 transcription factor in regulating left-right asymmetry and its impact on the development of atrial fibrillation (AF), the most common sustained heart rhythm disorder affecting 5% of the U.S. population. The research aims to investigate PITX2-dependent epigenetic remodeling during left-right determination, the impact of PITX2 on oxidative stress response, and the mechanisms of PITX2-mediated transcriptional repression. The award has an initial period of performance from September 2025 through July 2028 and supports the hospital's ongoing efforts to advance the understanding of the genetic and molecular factors underlying AF to develop more effective therapies.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 8/7/25 |