The National Heart, Lung, and Blood Institute (NHLBI) awarded a $769,761 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Weill Medical College of Cornell University to study the mechanisms of obesity-induced atrial fibrillation. The research aims to investigate the role of the NAD+ pathway and ATF6 ER stress pathway in the development of atrial fibrillation triggered by obesity. Specifically, the project will: 1) Dissect the role of the NAD+ pathway in obesity-induced atrial fibrillation, and 2) Assess the role of the ATF6 ER stress pathway in obesity-induced atrial fibrillation. The overall goal is to gain greater insight into the molecular mechanisms underlying the link between metabolic diseases and atrial fibrillation, which may lead to new treatments to prevent or improve this condition. The award period runs from January 22, 2025 to November 30, 2028.
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