The U.S. National Heart, Lung, and Blood Institute (NHLBI) awarded a $361,083 Project Grant (CFDA 93.837 Cardiovascular Diseases Research) to Childrens Hospital Medical Center in Cincinnati, Ohio to study how acetylation regulates the subcellular localization and activity of the transcription factor YAP in the context of cardiac regeneration. The project aims to investigate how metabolic stress and the NAD+/SIRT1/2 axis modulate YAP acetylation, and whether combined targeting of the Hippo pathway and YAP acetylation can enhance cardiac regeneration more effectively than targeting either pathway alone. This research could lead to the development of new therapeutic strategies for treating ischemic heart diseases. The award period runs from January 1, 2025 to November 30, 2029.
Generated 1/28/25, 9:27 AM