Project Grant R00HL161406
- This federal Project Grant award of $621,546.00, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), focuses on observing the single molecule dynamics of the catalytic subunit of cAMP-dependent protein kinase A (PKA-C) under both normal and disease-associated conditions. The primary objectives are to: 1) Engineer a single-walled carbon nanotube field effect transistor (SWNT FET) system to record PKA-C single molecule...
- The federal Project Grant award R01HL177433, funded by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), supports a research project to investigate the structural dynamics and regulatory mechanisms of the Atrial Natriuretic Peptide Receptor (ANPR or GC-A) over a period of 4 years from December 2024 to November 2028. The $535,213 grant awarded to Weill Medical College of Cornell University aims to: 1) delineate the structural changes in GC-A upon...
- This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (CFDA 93.853), supports research to understand how G protein-coupled receptors (GPCRs) regulate cellular functions in cardiomyocytes and neurons. The $396,031 award to the Augusta University Research Institute, Inc. will map the subcellular distribution of heterotrimeric G proteins, investigate how G proteins move upon receptor activation, and determine if G proteins are concentrated at specific...
- This federal Project Grant award of $125,000.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to New York University School of Medicine. The research project aims to elucidate the role of the cyclin D1-CDK4/6 complex in regulating protein homeostasis, with a focus on understanding how cyclin D-dependent phosphorylation modulates key effectors of the endoplasmic reticulum-associated...
- This Project Grant award, valued at $1,088,500.00, was provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to The University of Iowa. The award supports three independent research projects related to genetic and molecular mechanisms of heart disease. Project #1 aims to define microRNA (miR) targeting events and their biological relevance in the heart, as well as understand the clinical significance of single nucleotide polymorphisms (SNPs)...
- This $713,511 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research into the impact of myosin-binding protein C (MyBP-C) on myosin mobility and proteostasis in the context of hypertrophic cardiomyopathy (HCM). The University of Vermont & State Agricultural College, the awardee, will utilize innovative techniques to investigate how reduced MyBP-C levels, a common cause of HCM, may disrupt normal heart...
- This federal Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $766,667 to the Augusta University Research Institute, Inc. to investigate the role of neddylation, a protein modification process, in the development of cardiovascular diseases. The research aims to determine the significance of neddylation in maintaining vascular smooth muscle cell homeostasis and overall vascular health. Key research activities include...
- The National Institute of General Medical Sciences (NIGMS) awarded a $377,123 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Research Foundation for the State University of New York (RF SUNY) on September 1, 2025. The grant supports a research program aimed at providing structural and mechanistic insights into the ligand specificity of A1-adrenergic receptors (A1-ARs) through the use of cryo-electron microscopy, biochemical, and cellular studies....
- The University of Rochester was awarded a $226,101 Project Grant from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to conduct research on pulmonary angioblasts and their role in vascular development. The project aims to leverage existing single-cell RNA sequencing data to uncover novel insights into the cellular characteristics and regulatory mechanisms governing pulmonary angioblasts, which are critical for vascular regeneration and the...
- This Project Grant award of $576,786.00, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports research at the University of Arizona to investigate the role of the YTHD2 protein in regulating the translation of the NRF2 protein under conditions of oxidative stress. The research aims to elucidate the mechanisms by which certain proteins, like NRF2, can continue to be translated despite the general inhibition of protein...
This Project Grant award, with a total funding amount of $249,000.00, was provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research program) to the University of Rochester in Rochester, NY. The grant supports research to structurally and biochemically characterize functional signaling assemblies of adenylyl cyclase, as well as visualize the topography and dynamics of adenylyl cyclase microdomains in response to cyclase activation. This research aims to provide a substantial leap forward in the understanding of adenylyl cyclase biology, which is critical for developing therapeutics targeting cyclic AMP pathways. The grant project has an award date of August 1, 2025 and a scheduled completion date of July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 7/30/25 |