The National Heart, Lung, and Blood Institute (NHLBI) awarded a $535,213 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to Weill Medical College of Cornell University to conduct research on the structural dynamics and regulatory mechanisms of the Atrial Natriuretic Peptide (ANP) receptor, also known as GC-A. The research aims to elucidate the structural changes that occur in GC-A upon binding of ANP, understand the role of the receptor's Kinase-Homology Domain in regulating its activation, and clarify the conformational dynamics governing the catalytic activity of the receptor. This work is expected to significantly advance the understanding of GC-A's structure-function relationship and its regulatory mechanisms, with potential implications for developing targeted therapeutic interventions for cardiovascular diseases. The grant award period extends from Dec 15, 2024 to Nov 30, 2028.
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