Project Grant R01AR083904

The University of Texas Southwestern Medical Center (UT Southwestern) was awarded a $588,302 federal Project Grant (R01AR083904) from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846). The grant supports research to establish the necessity and sufficiency of glutamine metabolism in regulating osteoclast differentiation and bone resorption, evaluate the efficacy of a glutaminase inhibitor in inhibiting bone resorption, and define the mechanisms by which glutamine-derived purine biosynthesis regulates osteoclast metabolism and differentiation. This research aims to improve the understanding of metabolic regulation during osteoclast activity and pathological bone loss, with broad implications for bone homeostasis. The 5-year project is scheduled to run from February 1, 2025 to January 31, 2030.