Project Grant R00HD107908
- This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is focused on identifying novel noncoding genetic mechanisms that contribute to developmental disorders. The $499,055.48 award, with a project period from November 1, 2024 to October 31, 2027, will fund research led by Dr. Chelsea Lowther at the Icahn School of Medicine at Mount...
- The Project Grant award titled "Asymmetric RNA Segregation in Neural Stem Cells" was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $392,004 grant will support research at the University of Washington to identify and characterize asymmetrically segregating RNA molecules in fly neural stem cells, with the goal of understanding how RNA partitioning contributes...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $133,401 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Fred Hutchinson Cancer Center, located in Seattle, WA. The grant, awarded on September 1, 2025, is intended to develop computational models that can identify the sequence of changes a cell undergoes during differentiation and maturation, and compare changes in gene expression...
- This federal Project Grant award for $378,123 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to identify and test mechanisms that establish transcriptional regulatory potency in early embryos. The primary activities include using genomic methods like PRO-seq, DREG, and OMNI-ATAC to characterize transcriptionally active regulatory elements, DNA accessibility, and...
- The Trustees of Columbia University in the City of New York was awarded a $638,625.00 Project Grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) on August 21, 2025. The project, titled "In Vivo Regulation of Progenitor Genome Organization and Cellular Diversity", aims to investigate how the physical organization of the genome in neural progenitor cells impacts their ability to generate diverse neuronal subtypes during brain...
- The National Institute of Child Health and Human Development (NICHD) awarded a Project Grant of $107,948 to New York University (NYU) on June 20, 2025 under the Child Health and Human Development Extramural Research (CFDA 93.865) program. The grant aims to enhance the understanding of motor neuron differentiation, which is critical for addressing spinal muscular atrophy and amyotrophic lateral sclerosis - neurological disorders affecting nearly 1 in 10,000 people globally. The research will...
- The Project Grant award titled "UNDERSTANDING FUNCTIONS OF LTR RETROTRANSPOSON ACTIVATION IN PREIMPLANTATION DEVELOPMENT" is funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $401,927 award supports research to understand how long terminal repeat (LTR) retrotransposons regulate zygotic gene activation and early embryogenesis. The research...
- This federal Project Grant award of $128,898 was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research to elucidate how the 3D genome regulates the transcriptional program during mouse spermatogenesis, with the goal of providing insight into how male germ cell identity is established. The principal investigator will perform high-resolution Hi-C analysis...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund research to investigate the impact of coding and non-coding mutations in the ARID1B gene on neurodevelopmental disorders (NDDs). The $294,408 award, spanning November 2024 to May 2027, will enable Emory University to characterize ARID1B haploinsufficient mice at the...
- The federal Project Grant award titled "MECHANISMS OF DOUBLE STRAND BREAK REPAIR IN FETAL MALE GERM CELLS" was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $107,458 award, granted on May 1, 2025, supports research at Duke University to determine how male germ cells in the fetal stage repair double-strand DNA breaks and maintain genomic...
This Project Grant award of $248,994 was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), which administers the Child Health and Human Development Extramural Research Federal Grant Program (CFDA 93.865). The award will fund research by the Washington University in New York, NY to investigate the mechanisms by which histone mutations affect chromatin structure, gene expression, and neural differentiation during development. The goal is to elucidate the physiological functions and underlying mechanisms of histone germline mutations, which have been recently identified in children with developmental disorders but whose impacts remain largely unknown. The project will employ biochemical and genomic assays, as well as mouse models, to uncover how histone mutations alter heterochromatin silencing and promote neural differentiation, ultimately contributing to brain defects. This 3-year project commenced on August 1, 2025.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 8/8/25 |