The National Institute of Child Health and Human Development (NICHD) awarded a $1,376,850 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to the University of Colorado-Denver on August 9, 2024. The goal of this 5-year project is to compare the gut microbiome, immune responses, and respiratory microbiome of HIV-exposed uninfected (HEU) and HIV-unexposed (HU) infants, and test dietary interventions to modulate the HEU gut microbiome and immune function. The...
This $315,000 federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will be used by the Regents of the University of California at Riverside to conduct research on the interactions between the vaginal virome and bacterial vaginosis (BV), as well as the impact on HIV acquisition risk. The study aims to characterize the vaginal virome and its role in BV...
This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) provides $533,750.00 to the University of Florida to study the role of macrophages in the increased HIV risk associated with bacterial vaginosis (BV). The research aims to determine how a non-optimal vaginal microbiome affects the activation and "training" of macrophages towards an HIV-permissive phenotype. This will be...
This $756,077 Project Grant was awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports a 5-year research study to investigate the long-term immunologic, cardiovascular, metabolic, and neurocognitive outcomes in children and adolescents with perinatal HIV infection who have achieved viral suppression on long-term antiretroviral therapy. The research will assess...
This Project Grant award of $225,528 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research to investigate the mechanisms by which the maternal gut microbiome contributes to adverse fetal and perinatal outcomes after influenza A virus (IAV) infection during pregnancy. The central hypothesis is that IAV-induced changes in the diversity and composition of the maternal gut...
This Project Grant award of $210,600 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to investigate the role of "public" immunoglobulin A (IgA) antibodies in regulating the gut microbiome and inflammation in persons living with HIV-1 (PWH). The key objectives are to: Prepare recombinant "public" IgA clonotypes found in HIV-1-uninfected individuals and PWH, and examine...
The National Institute of Child Health and Human Development (NICHD) awarded a $171,728 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to Weill Medical College of Cornell University to study the role of premature infant gut microbiome dysbiosis in mediating immune development and response to respiratory syncytial virus (RSV) infection. The research aims to define how the altered gut microbiome in premature infants impacts their ability to mount effective...
This Project Grant award of $193,582 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to determine the impact of the small intestine microbiota of undernourished mothers with environmental enteric dysfunction on vascular remodeling at the maternal-fetal interface. The research aims to characterize the effects of the gut microbiota on placental and fetal development,...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $412,500.00 in funding to the University of South Florida (USF) to conduct a longitudinal study of gut dysbiosis in anemic preterm infants. The goal is to determine the hematocrit threshold associated with gut microbiome changes and how anemia development influences the microbiome and host interactions...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $232,500 to The Johns Hopkins University to conduct research on the virologic determinants of very early antiretroviral treatment responses in infants with in utero HIV-1 infection. The key objectives of this 2-year project are to create infectious molecular clones from the proviral HIV-1 DNA of...
This $498,000 Project Grant awarded by the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 (Child Health and Human Development Extramural Research) supports research to identify interactions between the gut virome, bacterial microbiota, and cellular immune responses in HIV-exposed but uninfected infants. The study aims to longitudinally analyze viral metagenome data, bacterial community composition, and T cell cytokine responses to the BCG vaccine in 40 HIV-exposed uninfected and 40 unexposed infants. Additionally, the researchers will assess the causal effects of an expanded virome on the bacterial microbiome and BCG vaccination responses in gnotobiotic mouse models, as well as profile mucosal and peripheral gene expression changes using single-cell RNA sequencing. The ultimate goal is to elucidate mechanisms underlying gut dysbiosis in HIV-exposed infants and identify potential interventions to restore their health.