This Project Grant award of $769,644 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to functionally characterize the lysosome membrane and its protein quality control system. The primary objectives are to: 1) identify substrates of lysosomal E3 ligases in humans, 2) investigate the assembly of the ESCRT machinery to the lysosome membrane for internalizing ubiquitinated cargoes, and 3) determine the...
This federal Project Grant award, with ID R35GM154651, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The $381,250 award, effective September 1, 2024 through August 31, 2029, will support research at the University of New Mexico Health Sciences Center (UNM HSC) to investigate the cellular mechanisms underlying the response to lysosomal damage. The research aims to establish the function of...
This Project Grant award for $316,368.00 was provided by the National Institute of General Medical Sciences (NIGMS), which administers the Biomedical Research and Research Training (CFDA 93.859) federal grant program. The grant will fund research to understand the mechanisms of metabolic adaptation in cells, focusing on the autophagy and cytochrome P450 pathways. The research aims to elucidate how these pathways respond to nutrient scarcity and chemical stressors, using advanced genomics,...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $148,568 to the University of Massachusetts to investigate the interactions of the enzyme UDP-glucose:glycoprotein glucosyltransferase (UGGT) with its substrates and co-chaperone. The goal is to utilize cellular and biophysical experiments to gain structural insights into the concerted action of UGGT and its co-chaperone protein Sep15...
This Project Grant award of $379,394 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to uncover the molecular mechanisms behind hydrogen peroxide (H2O2)-mediated protein regulation. The research plan includes four key projects: 1) identifying proteins directly oxidized by high H2O2 levels that activate and deactivate specific transcription factors and kinases, 2) using proteomics to map...
This federal Project Grant award of $644,900.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on PAS (Period-ARNT-Single-Minded) domain proteins. The research aims to obtain mechanistic insights into how these ubiquitous signaling proteins, found across all kingdoms of life, detect and respond to changes in environmental conditions. Specifically, the research will utilize...
This $145,642 federal Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research at William Marsh Rice University to investigate the role of autophagy inducers and peroxisomal proteins in pexophagy. The research aims to improve understanding of peroxisome regulation, which could have implications for metabolic illnesses in humans and metabolic engineering in crops. The key products or...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training federal grant program (CFDA 93.859), is funding research by The Ohio State University to investigate lysosomal membrane dynamics under stress conditions. The $393,750 award, which runs from February 1, 2025 to January 31, 2030, aims to provide a better mechanistic understanding of lysosomal quality control and potential therapeutic applications. Key...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $528,129 to the University of Connecticut Health Center to conduct research on the ubiquitin-proteasome pathway and its role in human disease. The key objectives of this 5-year research program are to: Structurally and functionally characterize critical ubiquitinating and de-ubiquitinating enzymes implicated in human...
This $380,540 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to decipher new principles of rapid proteostatic control and develop spatiotemporal lysosomal tools. The key research activities include: 1) defining novel protein substrates and motifs required for lysosomal delivery, 2) determining the functional impact of methyl-driven lysosomal proteolysis on...