Project Grant R00DA058974
- This federal Project Grant award, funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research on the impact of oral THC consumption during adolescence on the adult mouse brain. The $716,455 award, effective July 1, 2025 through March 31, 2030, will enable researchers at the University of Washington to: Determine how long-term adolescent use of THC-gelatin, alone or in combination with cannabidiol (CBD), impacts...
- This $507,000.00 federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research at the Icahn School of Medicine at Mount Sinai to investigate the epigenetic mechanisms underlying cannabis use disorder. The project, running from September 1, 2025 to May 31, 2030, aims to leverage a translational animal model of voluntary THC consumption to study sex differences and individual variability in...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $621,186 to the University of Wisconsin - Milwaukee to examine the longitudinal impact of circulating endocannabinoid levels on neurocognition, impulsivity, and early cannabis use patterns in youth enrolled in the Adolescent Brain Cognitive Development (ABCD) Study. The project aims to investigate the role of the endocannabinoid system in...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will provide $350,000 to Creighton University to investigate the effects of environmental enrichment on the abuse liability of minor cannabinoids such as delta-8-THC and CBD. The research aims to determine if adolescent exposure to high- or low-novelty environments can alter sensitivity to these cannabis compounds using animal models....
- This federal Project Grant award of $429,000.00 was provided by the National Institute on Drug Abuse (NIDA), which falls under the Drug Use and Addiction Research Programs (CFDA 93.279), to Oregon Health & Science University (OHSU). The objective of this project is to develop and apply new tools to precisely manipulate the effects of tetrahydrocannabinol (THC), the main psychoactive compound in marijuana, on the brain's reward circuitry. Specifically, the researchers have created...
- This federal Project Grant award of $385,638 was provided by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, under the Drug Use and Addiction Research Programs (CFDA 93.279). The purpose of the grant is to conduct research on the neurobehavioral consequences of chronic exposure to synthetic cannabinoids, also known as "synthetic marijuana", across different stages of lifespan development and between sexes. The research aims to elucidate the...
- The U.S. National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, awarded a $686,692 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Medical University of South Carolina. The grant will fund an 8-week clinical trial to assess the prospective changes in patient-reported and objective functioning following reduction of cannabis use among adults with cannabis use disorder. The trial will evaluate the benefits of cannabis harm...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $1,320,580 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Washington University in Missouri. The grant will fund preclinical studies to evaluate the analgesic potential of a novel, peripherally-restricted cannabinoid type 1 receptor (CB1R) agonist called VIP36. The key objectives are to assess VIP36's efficacy in mouse models of post-traumatic headache,...
- This Project Grant award of $153,000.00, funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), will support a 6-month longitudinal study examining the relationships between naturalistic cannabis use, pain perception, and functioning (e.g., pain-related disability, physical activity, sleep) in the daily lives of young adults with chronic pain. The study will use an ecological momentary assessment burst design to capture...
- This federal Project Grant award of $476,496.00, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research at American University investigating the role of opioid signaling in reward-guided decision-making within the rat prefrontal cortex. The project, led by the Principal Investigator, will utilize intra-cortical pharmacology, computational modeling, and video analysis to examine how cortical opioid receptors...
This federal Project Grant award, valued at $249,000.00 and provided by the National Institute on Drug Abuse (NIDA), supports a research project titled "ENDOCANNABINOID REINFORCEMENT OF PHYSICAL ACTIVITY" under the Drug Use and Addiction Research Programs (CFDA 93.279). The project aims to explore whether enhancing the action of endocannabinoid receptors (CB1) during physical activity can increase positive affective states, leading to greater long-term physical activity participation. The award, with a performance period from August 1, 2025 to July 31, 2028, will be executed by the University of Texas at Austin, a prominent public research institution with extensive expertise in federally funded scientific research. The research project comprises three specific aims: 1) determining whether endocannabinoid release in the ventral tegmental area reinforces wheel running, 2) evaluating whether amplification of CB1 activity response to endocannabinoids by a CB1 positive allosteric modulator (PAM) increases wheel running in mice that are innately low wheel runners, and 3) assessing whether amplification of CB1 activity response to endocannabinoids via a CB1 PAM increases wheel running.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 7/31/25 |