Project Grant R00CA276895
- Federal Grant Award Summary The National Cancer Institute (NCI), under the Cancer Cause and Prevention Research program (CFDA 93.393), awarded the University of Alabama a Project Grant of $2,524,071 on September 23, 2025, for research investigating the neurocomputational mechanisms underlying self-regulation and reinforcement learning in smoking cessation decisions. The four-year project, with completion scheduled for August 31, 2029, will employ computational model-based multimodal neuroimaging...
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $228,195 Project Grant from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), effective July 1, 2026, through June 30, 2028. The award funds the development and validation of multimodal predictive models designed to identify radiation failure patterns and predict survival...
- Federal Grant Award Summary The Medical University of South Carolina received a $586,018 Project Grant from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393), awarded July 10, 2026, with a completion date of May 31, 2031. This fully-powered three-arm clinical trial will develop and test augmented-dose nicotine replacement therapy (NRT) interventions for individuals who use both combustible cigarettes and e-cigarettes and seek to quit both...
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $526,939 Project Grant award from the National Cancer Institute (NCI) on July 10, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394). The award funds research through June 30, 2031, to develop innovative imaging biomarkers and multimodal deep learning models that integrate radiological, pathological, and clinical data to predict immunotherapy response and survival outcomes in...
- Federal Grant Award Summary Wake Forest University Health Sciences received a $683,782 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded March 1, 2026, with completion targeted for December 31, 2030. The project, titled "Computationally Assisted Multi-Neurotransmitter Detection for Intracranial Research," develops computational methods to enable simultaneous real-time detection of dopamine,...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the University of North Carolina at Chapel Hill $713,290 under the Cancer Biology Research program (CFDA 93.396) to investigate mechanisms of ATF4 (Activating Transcription Factor 4)-directed macrophage dysfunction in melanoma. The award, obligated on July 6, 2026, with an ultimate completion date of June 30, 2031, supports fundamental research on how chronic ATF4 activity in tumor-associated macrophages (TAMs)...
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $105,076 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective December 1, 2025, with a completion date of December 31, 2027. This fellowship award supports research investigating the neurocomputational basis of effort-based decision making (EBDM) in individuals with tobacco use disorder (TUD), concurrent tobacco and...
- Federal Grant Award Summary Wake Forest University Health Sciences received a $402,728 Project Grant from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded July 16, 2025, with completion targeted for June 30, 2027. The award supports development of interpretable deep learning models for multi-modality imaging-based gastric cancer prognosis. The project addresses the critical clinical need to improve prognostic accuracy and...
- Federal Grant Award Summary Wake Forest University Health Sciences received a $622,071 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) to investigate microbiota-derived metabolite signaling as a mechanism to reduce obesity-mediated breast cancer risk. The award, effective May 1, 2026 through April 30, 2031, supports fundamental cancer biology research examining how hippurate—a microbial-host co-metabolite—activates G-protein...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Wake Forest University Health Sciences a $952,155 Project Grant effective August 15, 2025, through April 30, 2030, under the Drug Use and Addiction Research Programs (CFDA 93.279). This research project investigates the impact of nicotine and alcohol co-use on cocaine abuse potential using cynomolgus monkey models to address cocaine use disorder (CUD), a major public health challenge with no FDA-approved...
Wake Forest University Health Sciences received a $473,071 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), effective January 1, 2026, through December 31, 2028. The award funds research investigating the molecular mechanisms by which nicotine promotes brain metastasis in lung cancer patients by activating GABAergic (gamma-aminobutyric acid-releasing) neurons. The research will elucidate the pathway through which nicotine stimulates microglia to secrete exosomal microRNA-32-3p, which in turn enhances GABAergic synaptic formation and supplies GABA as a metabolic substrate to fuel tumor cell growth. The funded research comprises three primary aims: (1) clarifying the molecular pathway by which nicotine activates GABAergic neurons through microglia-derived exosomal microRNA-32-3p; (2) investigating how activated GABAergic neurons enhance brain metastasis through GABA transporter activity in tumor cells; and (3) testing the efficacy of GABA transporter inhibitors as therapeutic agents to suppress nicotine-stimulated brain metastasis. These research activities are designed to develop innovative treatment strategies for patients with lung cancer brain metastasis, a condition currently characterized by extremely poor prognosis and high mortality rates. The work will be conducted in Winston-Salem, North Carolina.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $24.9k | 4/20/26 | ||
| Not listed | $224.1k | 2/24/26 | ||
| Not listed | $224.1k | 2/24/26 |