The National Institute on Aging (NIA) awarded a $730,089 Project Grant under CFDA 93.866 (Aging Research) to Washington University in St. Louis. The purpose of this 5-year study, titled "LIFE-SPACE, ISOLATION, AND FUNCTIONAL EXPOSOME STUDY IN PRECLINICAL ALZHEIMER'S DISEASE AND COGNITIVE ENVIRONMENTS (LIFESPACE)", is to examine the use of digital markers from everyday activities, such as driving and physical activity, to identify biological indicators of preclinical Alzheimer's disease...
This $3,465,141 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) supports the development and evaluation of Onward Health, Inc.'s technology-enabled door-through-door rideshare service with trained companion drivers. The service aims to improve transportation access and support for older adults and individuals with Alzheimer's disease and related dementias (AD/ADRD). Key objectives of the 20-month project include: (1) conducting a randomized controlled...
This Project Grant award of $309,550.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a study to develop and apply a novel "physical activity (PA) complexity" metric using accelerometer data to explore associations between PA patterns, cognitive function, and risk of Alzheimer's disease and related dementias (ADRD) in an older adult population. The key objectives are to: (1) examine the links between PA complexity, cognitive performance, and risk of...
This Project Grant award of $3,177,045 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a 20-year longitudinal study examining psychosocial risk and protective factors for cognitive functioning among middle-aged and older Black Americans. The primary awardee, the Regents of the University of Michigan, will re-interview approximately 2,600 participants from the National Survey of American Life to collect longitudinal data on factors influencing cognitive and physical...
The University of Washington received a $760,779 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to conduct a geographically granular assessment of the present and future impacts of extreme temperature on aging populations in the United States by race and ethnicity. The 5-year research project, beginning January 1, 2025, aims to estimate the burden of extreme temperature, understand how risk factors modify the effects, and assess the potential for risk...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $1,550,751 will support an investigation of the influences of historical, enduring, and contemporary structural racism on racial disparities in cognitive aging, functional decline, and frailty trajectories. The research will leverage data from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) epidemiological cohort study and will involve up to 800 participants tracked...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $203,278 to Brandeis University from November 2024 to January 2026 to conduct research on the neurobiological mechanisms underlying daily life activity participation in older adults and its relationship to Alzheimer's disease pathology. The project will use a multilevel, multimodal framework including behavioral, psychophysiological, neuroimaging, and naturalistic approaches to understand...
This Project Grant award from the National Institute on Aging (NIA) under CFDA 93.866 Aging Research provides $413,476 to the University of Maryland, College Park to conduct research on the acquisition of disability and chronic morbidity by older Indians following extreme urban coastal flooding events. The study aims to: (1) estimate the impact of these extreme flooding events on disability and chronic disease in the urban older population in India; (2) analyze changes in housing, living...
The National Institute on Aging (NIA) awarded a $1,928,657 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the Regents of the University of Michigan, doing business as the University of Michigan. The 3-year project aims to develop and evaluate new measures of family availability to provide care for people living with Alzheimer's disease and related dementias (ADRD). The study will leverage national survey data to: 1) Create sub-indices and a composite measure of...
This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) aims to investigate the landscape of transposable elements (TEs) and their association with Alzheimer's disease (AD) and related dementias (ADRD). The $303,449 award, granted on June 1, 2025, will support the development of a novel cloud-based infrastructure to analyze large genomic datasets and assess the potential functional impact of AD-relevant TEs. The project will identify...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), will support research to examine the impact of public transit accessibility on physical activity and social participation among older adults with and without disabilities.
The $913,711.04 award, spanning September 2024 to August 2027, will enable the Regents of the University of Michigan to collect primary data on public transit accessibility features and link them to the National Health and Aging Trends Study. The research aims to: 1) assess if self-reported public transit use is associated with physical activity and social participation, 2) determine if public transit system accessibility is linked to these health behaviors, and 3) test if public transit use mediates the relationship between transit features and physical activity/social participation. This research could identify modifiable public transit factors that impact healthy aging for older adults, particularly those with disabilities.