Project Grant R00AG081552

Award Date 8/15/24
Completion Date 7/31/27
Dollars Obligated $523K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Gainesville, FL 32611, USA
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The National Institute on Aging (NIA) awarded a $2,330,235 Project Grant under the Aging Research program (CFDA 93.866) to Rush University Medical Center in Chicago, Illinois. The grant, which runs from September 15, 2024 to June 30, 2029, will support research examining the relationship between diet, neuroinflammation, brain oxidative stress, and plasma neurodegenerative biomarkers in a diverse population to elucidate the link between diet and Alzheimer's disease/age-related dementias...
The National Institute on Aging (NIA) awarded a $656,000 Project Grant (CFDA 93.866 - Aging Research) to The Regents of the University of California, San Francisco (UCSF) to investigate the role of hyperalgesic priming in chronic pain experienced by the elderly. The research aims to: 1) establish that aged rats exhibit nociceptor plasticity (priming) and determine if it is associated with systemic inflammation, and 2) identify the mechanisms underlying priming in the elderly, including the...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), provides $507,371 to the University of Florida to study the role of CASP8 microsatellite repeat expansions in Alzheimer's disease (AD). The project aims to: 1) Investigate the accumulation of CASP8 repeat expansion RNA and proteins in AD patient brains, 2) Examine the association between CASP8 repeat expansions and AD pathological hallmarks in patient-derived...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support Emory University's research into the genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease and related dementias. The $528,876 award, effective June 1, 2025, will fund the development of new analytic tools to integrate genomic data across multiple tissues and improve the identification of genetic risk factors and underlying molecular mechanisms for...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to evaluate the effects of poverty alleviation policies on the risk and disparities of Alzheimer's disease and related dementias (AD/ADRD). The $131,813 award to Trustees of Boston University, awarded on May 1, 2025, will support a research program with two key objectives: In the K99 phase, the researcher will integrate Health and Retirement Study (HRS) and Medicare data to quantify state-level...
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) for $522,764.82 will fund a research study entitled "PAIN AND NUTRITION IN DEMENTIA AND ALZHEIMER'S-2 (PANDA-2)" at the University of Florida. The study aims to determine the influence of overall diet pattern as well as vitamins A and D on the epigenetic environment as it relates to chronic pain and Alzheimer's disease/related dementias. The research will consist of two phases - the first (K99 phase) will assess dietary differences and their associations with epigenetic aging, pain, and cognition, while the second (R00 phase) will evaluate the impact of diet pattern and vitamin A/D status on DNA methylation, gene/protein expression, pain, and cognitive outcomes in older adults with and without mild cognitive impairment. This work extends the principal investigator's prior research on dietary and immune system modulation of pain, and seeks to identify nutrigenomic targets to improve pain and dementia outcomes in older adults.

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