Project Grant P50DA066459
- The National Institute on Drug Abuse awarded the University of California, San Diego $879,000 on March 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and validate a novel episode-based paradigm for studying how family processes drive adolescent substance use. The project will collect real-time, real-world intensive longitudinal data on discrete parent and youth behaviors before and after episodes of substance use from 90 adolescents who use substances....
- The National Institute on Drug Abuse awarded the University of California, San Diego $169,832 on September 30, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support research into the genetic basis of addiction-related behaviors. The project uses long-read sequencing technology to discover and characterize tandem repeats and structural variants in the genomes of N/NIH Heterogeneous Stock rats, genetic variants that conventional genome-wide association studies overlook....
- The National Institute on Drug Abuse awarded the University of California, San Diego $2.237 million on May 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and apply a community-informed modeling approach for HIV and hepatitis C virus prevention resource allocation among people who use drugs. The project will develop large language models trained on behavioral and biological data from multiple people-who-use-drugs cohorts to generate...
- The National Institute on Drug Abuse, part of the Department of Health and Human Services National Institutes of Health, awarded the University of California, San Diego $192,930 in project grant funding on May 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279). The award supports mentoring in patient-oriented research on central nervous system dysfunction in individuals with HIV and substance use. The funded activities provide protected time for the principal...
- The National Institute on Drug Abuse awarded the University of California, San Diego $165,669 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to identify behavioral and neural markers of opioid withdrawal-induced risk-taking and their relationship with relapse vulnerability. The research establishes and validates a translatable rodent model of opioid withdrawal to explore cognitive factors linked to relapse. The project uses the rat Iowa Gambling Task to...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA), under its Drug Use and Addiction Research Programs (CFDA 93.279), awarded $877,500 to the University of California, San Diego for a two-year project (July 15, 2025 through June 30, 2027) investigating neurobiological mechanisms underlying cocaine use disorder (CUD) susceptibility. The project employs a novel polygenic prediction methodology called RATTACA to identify pre-existing cellular differences in gabaergic and...
- The National Institute on Drug Abuse awarded New York University $103,607 on August 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct dissertation research on polysubstance use patterns and their associations with methadone maintenance treatment receipt and discontinuation among people who use drugs in New York State. The research uses a mixed-methods approach guided by the Social Ecological Model to identify latent polysubstance use patterns through urine...
- The National Institute on Drug Abuse awarded the University of California, San Diego $138,522 under the Drug Use and Addiction Research Programs (CFDA 93.279) on January 21, 2026. The award funds research evaluating the multiscale effects of fentanyl-induced dependence and abstinence within the mouse basolateral amygdala. The research employs virally-mediated strategies, nuclear labeling, and single-nucleus RNA sequencing to assess how fentanyl dependence and abstinence differentially affect...
- The National Institute on Drug Abuse awarded Loyola University of Chicago Health Sciences Campus $551,926 on May 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a large-scale longitudinal epidemiological study of polysubstance use and associated health outcomes. The recipient will leverage the Oracle EHR Real-World Data database, comprising 1.9 billion encounters from 113 million patients across 700 U.S. hospitals and clinics, to conduct four primary...
- The National Institute on Drug Abuse awarded the University of California, San Diego $239,125 on March 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) for a longitudinal multiparametric magnetic resonance imaging study of opioid use disorder vulnerability in rats. The recipient will conduct structural, diffusion, and functional MRI imaging on genetically heterogeneous stock rats sourced from the NIDA-funded Rat Oxycodone Biobank to characterize individual brain...
The National Institute on Drug Abuse awarded the University of California, San Diego $2,543,114 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to establish the Polysubstance Addiction Research Center, a five-year research initiative addressing polysubstance use disorders through integrated behavioral, molecular, circuit, and immunometabolic investigation. The center will conduct three primary research projects: brain connectomic analysis, brain transcriptomic profiling, and gut-vagus multiomic investigation. These studies will examine addiction-like behaviors across multiple drugs (cocaine, oxycodone, alcohol, and their co-use) in genetically diverse heterogeneous stock rats, with parallel analysis of human substance use disorder and alcohol use disorder cohorts. Specific Aim 1 will identify multilevel biomarkers of addiction-like behaviors by quantifying behavioral, neural, molecular, and immunometabolic signatures across sex, drug type, and addiction severity spectrum, applying advanced AI/ML methods to generate interpretable profiles of vulnerability and resilience. Specific Aim 2 will identify and validate druggable targets, including oxidative phosphorylation stress pathways and cholinergic and immune signaling pathways, using pharmacological and viral approaches in translationally-relevant relapse models. Specific Aim 3 will accelerate clinical translation. All multimodal datasets will converge into a single multiscale atlas serving as a reusable translational resource. The award supports work at UC San Diego's location in La Jolla, California, with a period of performance through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.5m | 8/31/26 |