Project Grant P01CA298993
- Federal Grant Award Summary Thomas Jefferson University (Sidney Kimmel Medical College) received a $484,405 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) effective September 1, 2025, through August 31, 2030. This five-year award supports fundamental cancer biology research investigating NSD2 (Nuclear Set Domain Family Member 2) mutations and their role in driving acute lymphoblastic leukemia (ALL) transformation. The research...
- Federal Grant Award Summary Thomas Jefferson University received a $646,208 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) beginning May 1, 2026 and concluding April 30, 2031. This award supports research investigating the spatial heterogeneity of Human Epidermal Growth Factor Receptor 2 (HER2) expression in luminal estrogen receptor-positive (ER+) breast cancer. The project aims to identify molecular targets and develop...
- Federal Project Grant Award Summary The National Cancer Institute awarded The Johns Hopkins University a $354,658 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective August 1, 2025 through July 31, 2030. This award supports fundamental research investigating subclonal P27 (CDKN1B) loss as a driver of aggressive prostate cancer, with particular focus on understanding health disparities affecting Black or African American males who experience prostate cancer mortality...
- Federal Grant Award Summary Thomas Jefferson University, operating as Sidney Kimmel Medical College, received a $401,115 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research program (CFDA 93.394) for the period August 1, 2025, through July 31, 2027. The award funds research to develop and validate contrast-enhanced ultrasound (CEUS) as a diagnostic tool for evaluating hepatocellular carcinoma (HCC) treatment response following transarterial...
- Federal Grant Award Summary Thomas Jefferson University's Sidney Kimmel Medical College received a $1,349,148 project grant from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420), awarded September 1, 2026, with completion targeted for August 31, 2030. The award funds research focused on the identification and evaluation of immune and targeted therapies for acral melanoma, a specialized cancer research initiative aligned with the DHA's...
- Federal Grant Award Summary Duke University received a $2.89 million Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) awarded August 1, 2025, with completion scheduled for July 31, 2029. This research project, titled "Understanding and Targeting Epigenetic Regulation of Immune Evasion in Prostate Cancer," will investigate how epigenetic mechanisms—specifically through the TNRC18 protein—regulate immune evasion in...
- Federal Grant Award Summary Duke University's Office of Research Administration received a $607,157 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective May 1, 2026 through April 30, 2031. This five-year research initiative addresses the urgent clinical need for new molecular targets to treat neuroendocrine prostate cancer (NEPC), an aggressive and lethal subtype with a five-year survival rate below 20%. The research...
- Federal Project Grant Award Summary Thomas Jefferson University's Sidney Kimmel Medical College received a $1.1 million Project Grant award from the Defense Health Agency (DHA) under the Military Medical Research and Development program (CFDA 12.420), effective June 1, 2026 through May 31, 2030. The grant supports research investigating how chemoradiation treatment imparts KRAS-mediated resistance to immunotherapy in non-small cell lung cancer. This project contributes to the DHA's broader...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The Trustees of Columbia University in the City of New York a Project Grant of $531,825 under the Cancer Biology Research program (CFDA 93.396) effective August 1, 2025, with completion targeted for July 31, 2030. This research initiative focuses on understanding the molecular mechanisms of castration sensitivity in prostate epithelium, with the ultimate goal of improving therapeutic responses to androgen-deprivation therapy...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the University of Pennsylvania a Project Grant of $148,626 under the Cancer Research Manpower program (CFDA 93.398), effective December 1, 2025, through April 30, 2028. This award supports research training and investigator development in cancer research aligned with the National Cancer Program's strategic priorities. The funding enables the institution to provide biomedical training opportunities and research career...
Thomas Jefferson University (Sidney Kimmel Medical College) received a $1.66 million Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) on March 6, 2026, with a completion date of February 28, 2031. This five-year award funds fundamental research to advance understanding of neuroendocrine prostate cancer (NEPC) progression and identify novel therapeutic vulnerabilities. The research program delivers comprehensive investigative services organized around three primary objectives: elucidating the mechanisms driving NEPC metastasis, determining how immune-inflammatory reprogramming of the tumor microenvironment shapes disease progression, and credentialing therapeutic targets exposed by tumor cell plasticity. The research is structured as an integrated program combining three research projects and a supporting core facility that collectively address critical knowledge gaps in NEPC pathophysiology. The award supports fundamental cancer biology research designed to generate actionable scientific findings for NEPC, a rapidly progressive condition representing approximately 25 percent of prostate cancer patients who develop resistance following androgen suppression therapy. By investigating the cellular and molecular mechanisms underlying NEPC's acute metastatic propensity and treatment resistance, the research endeavors to identify evidence-based therapeutic strategies for a disease currently carrying a median survival of seven months or less. The research products and deliverables will contribute to the broader scientific understanding of cancer cell plasticity, tumor microenvironment dynamics, and potential intervention points for this aggressive cancer variant.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.7m | 4/27/26 |