Project Grant NNX16AE07G

This federal Project Grant award, funded by the National Science Foundation's Engineering program (CFDA 47.041), supports research to grow three-dimensional cancer-myeloid organoids on the International Space Station (ISS) in order to better mimic brain tumor formation and study interactions between cancer and immune cells. The $400,000 award, with a project period from September 2024 to August 2027, will first generate "flight-ready" organoid seeds from various cancer and immune...

This National Cancer Institute (CFDA 93.393 Cancer Cause and Prevention Research) project grant award of $667,485 to the University of California, San Diego will fund a prospective longitudinal study to clinically characterize and understand the mechanisms underlying radiation-induced neurocognitive decline in patients with glioma. The study aims to: Characterize neurocognitive heterogeneity and identify cognitive phenotypes in glioma patients before and after radiotherapy (RT). Analyze...

The National Cancer Institute awarded a $406,217 Project Grant (CFDA 93.395 - Cancer Treatment Research) to the University of Texas Health Science Center at Houston (UTHealth) to study the role of circadian clock proteins in regulating astrocytic adenosine kinase and their impact on cognitive dysfunction following cranial radiotherapy for brain cancers. The research aims to determine how cranial radiotherapy disrupts the sleep-wake cycle and cognition by altering the expression of the...

This three-year, $4.84 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research at The Johns Hopkins University to investigate the neurological effects and cumulative risk of neurodegenerative disease from exposure to metal mixtures. Specifically, the researchers will examine the biological mechanisms by which exposure to mixtures of lead, arsenic, cadmium, and chromium during adulthood and early development cause...

This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $149,948 to The Leland Stanford Junior University to investigate the role of p53 signaling in radiation-induced coronary heart disease (RICHD), a leading cause of morbidity and mortality among cancer survivors. The key research activities involve using human-induced pluripotent stem cells (iPSCs) and transgenic mouse models to map gene...

This federal Project Grant award, provided by the National Science Foundation's (NSF) Engineering program (CFDA 47.041), supports a research project at Temple University to investigate how microgravity and radiation exposure impact the function of engineered human adipose (fat) tissue. The $399,994 award, with a performance period from December 2024 to November 2027, will involve sending engineered adipose tissue samples to the International Space Station (ISS) for a 6-month study. The...

This federal Project Grant award, titled "PET BIOMARKER FOR SYNAPTIC DENSITY CHANGES AFTER RADIATION THERAPY," is funded by the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394). The $1,474,236 award supports research to characterize changes in whole-brain synaptic density using novel Positron Emission Tomography (PET) imaging in rodent models after targeted radiation therapy. The project aims to establish a non-invasive biomarker...

This Project Grant from the National Institutes of Health's National Institute on Aging will fund research totaling $4,188,512 to the University of California, Davis from September 2022 through August 2025. The grant is part of the Aging Research program (CFDA 93.866), which supports biomedical, social, and behavioral research on aging processes and diseases affecting older populations. Specifically, the University of California, Davis will investigate the hypothesis that ultrafine particulate...

This Cooperative Agreement award, funded by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310), aims to investigate sex-based differences in how ionizing radiation exposure impacts the heart and lungs. The $544,248 grant, awarded on June 1, 2024, will support research at the University of Iowa to study the role of nitric oxide signaling and mitochondrial metabolism in mediating radiation-induced cardio-pulmonary dysfunction, particularly any...

This Project Grant award from the National Cancer Institute (CFDA 93.396 Cancer Biology Research) to SRI International provides $401,125 in funding to quantify the association between genetic factors and radiation sensitivity in cancer patients. The research aims to identify germline genetic variants and gene expression patterns that contribute to individual differences in radiation response. The goal is to develop a predictive screening platform to optimize radiation dosing and mitigate...