Project Grant K99NS151638
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Leland Stanford Junior University $682,281 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop a human induced pluripotent stem cell-based three-dimensional brain tissue microsphere model that recapitulates granulin deficiency phenotypes and associated pathology in neurodegenerative diseases including frontotemporal dementia and neuronal ceroid lipofuscinosis. The model...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded The Leland Stanford Junior University $122,526 on May 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Project Grant K99NS149164). Stanford will use the funding to delineate Alzheimer's disease initiation and propagation using novel adult human brain organoids. The work employs...
- The National Institute of Neurological Disorders and Stroke awarded Northwestern University $620,507 on August 14, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the association between TDP-43 dependent disruptions in RNA metabolism and neuronal excitability in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The research tests the hypothesis that TDP-43 dependent splicing errors on UNC13A...
- The National Institute of Neurological Disorders and Stroke, a component of the Department of Health and Human Services National Institutes of Health, awarded The Leland Stanford Junior University $432,647 on May 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate ferroptosis as a mechanism of post-hemorrhagic hydrocephalus following severe neonatal intraventricular hemorrhage. The research addresses the absence of...
- The National Institute on Aging awarded The Washington University $162,000 on March 1, 2026, under the Aging Research program (CFDA 93.866) to identify and characterize new therapy targets in TDP-43 proteinopathies. The award supports research into the mechanisms by which TDP-43 mislocalization results in neuronal death and aims to discover previously unidentified therapy targets that mediate this disease process. TDP-43 pathology is observed across multiple neurodegenerative diseases...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $3,081,936 to the University of California, San Diego on September 12, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This Project Grant, with a completion date of June 30, 2029, supports research investigating the mechanisms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) through multimodal...
- The National Institute of Neurological Disorders and Stroke awarded The Trustees of Columbia University in the City of New York $565,022 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of reactive oxygen species and ferroptosis in frontotemporal dementia. The research will assess mechanisms of neurodegeneration in frontotemporal dementia using in vitro and in vivo models. Work includes...
- The National Institute of Neurological Disorders and Stroke awarded the University of Arizona $1,764,771 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the pathological relevance of TDP-43 interactions with translation machinery in neurodegeneration. The award funds research into TDP-43 proteinopathy, which is characterized by mislocalization of tar DNA-binding protein 43 from the nucleus to the...
- The National Institute of Neurological Disorders and Stroke awarded The Leland Stanford Junior University $522,632 on July 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the role of pseudouridine synthase PUS7 in neurodevelopment. The recipient will use two-dimensional and three-dimensional in vitro neuronal differentiation systems, primary tissues and cells, cutting-edge sequencing tools for RNA modification...
- The National Institute of Neurological Disorders and Stroke (NINDS) of the Department of Health and Human Services awarded Yale University $446,670 on May 6, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop and validate bi-functional helical peptides that inhibit TDP-43 aggregation. TDP-43 mislocalization and aggregation is central to amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration with TDP-43...
The National Institute of Neurological Disorders and Stroke awarded The Leland Stanford Junior University $124,794 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate microglial iron and lipid dysregulation in TDP-43-related neurodegeneration. The funded research will determine whether TDP-43-related neurodegeneration drives microglial ferroptosis by affecting microglial iron and lipid metabolism, define the microglia-astrocyte crosstalk that regulates microglial iron metabolism through the IL-6-hepcidin pathway, and establish how gut-derived systemic inflammation perturbs brain iron homeostasis in TDP-43-related neurodegeneration. The work combines an inducible TDP-43 mouse model with analyses from individuals with amyotrophic lateral sclerosis (ALS), addressing iron dysregulation as a potential trigger for ferroptosis—an iron-dependent cell death mechanism driven by toxic lipid peroxide accumulation in the brain's primary iron-storing and debris-clearing cells. Performance occurs in Palo Alto, California, with the period of performance running through July 31, 2028. This is a Project Grant providing extramural research funding to support basic neurological science that explores fundamental brain and nervous system structure and function to reduce the burden of neurological disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $124.8k | 8/7/26 |