Project Grant K99NS146256
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a $1,459,072 Project Grant on August 1, 2025, under the Aging Research program (CFDA 93.866) to investigate inhibitory neuron dysfunction in Alzheimer's disease (AD). The research will develop and implement innovative methodologies to monitor and manipulate two distinct inhibitory interneuron cell populations—parvalbumin (PVALB) and somatostatin (SST) cells—in both wildtype and AD-knock-in...
- Federal Grant Award Summary The J. David Gladstone Institutes received a Project Grant award of $1.38 million from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, effective September 1, 2025, through August 31, 2033. This eight-year research initiative focuses on understanding neurovascular interactions and their role in central nervous system (CNS) diseases...
- Federal Grant Award Summary The National Institute on Aging awarded J. David Gladstone Institutes a Project Grant of $790,288 (awarded February 15, 2026, with completion by November 30, 2030) under the Aging Research program (CFDA 93.866) to conduct genetic research on the 17q21.31 MAPT locus associated with Alzheimer's disease and related dementias. The primary deliverable is a comprehensive genetic dissection study utilizing statistical genetics and machine learning methodologies to identify...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $521,839 to the University of California, San Diego on August 7, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This five-year project grant, scheduled for completion by July 31, 2030, supports fundamental research investigating the mechanisms of pathogenic microglial populations in central nervous system (CNS)...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant totaling $804,450 (awarded June 1, 2025, with completion targeted for March 31, 2030) under the Aging Research program (CFDA 93.866) to conduct biomedical research investigating the molecular mechanisms underlying Apolipoprotein E4 (APOE4)-driven pathogenesis in Alzheimer's disease (AD). The research will focus on targeting the growth factor protein NELL2 (Neural...
- Federal Grant Award Summary The J. David Gladstone Institutes received a $630,496 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) for the period June 1, 2025, through March 31, 2030. The award funds research investigating proteostasis dysfunction, neuroinflammation, and neurodegeneration in frontotemporal dementia (FTD) caused by GRN (granulin) haploinsufficiency. The research will examine how GRN deficiency impairs the autophagy/lysosomal...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded Boston Children's Hospital a $489,500 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) for the period July 1, 2025 through June 30, 2027. This R21 exploratory research grant supports a collaborative investigation into stimulus-responsive microproteins in human microglia-like cells, focusing on mRNA translational...
- Federal Grant Award Summary J. David Gladstone Institutes received a Project Grant award of $817,357 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 15, 2025, with a completion date of March 31, 2030. The award supports research applying novel machine learning (ML) approaches to behavioral analysis and brain signal integration in humanized Alzheimer's disease (AD) models. The primary deliverable involves validation and development of a...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $127,224 to the University of California, San Diego on October 24, 2025, under the Aging Research program (CFDA 93.866) to support scientific investigation into the pathological mechanisms of Alzheimer's disease (AD). The project, which extends through August 31, 2028, will elucidate the role of s-nitrosylated phospholipase D3 (SNO-PLD3) in microglial and neuronal pathophysiology associated with AD. Specifically,...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Johns Hopkins University a $622,086 project grant on May 15, 2025, under the Aging Research program (CFDA 93.866) to conduct research investigating microglial NOD2/RIPK2 (nucleotide-binding oligomerization domain-containing protein 2/receptor-interacting serine/threonine-protein kinase 2) signaling in Alzheimer's disease (AD) pathophysiology. The research project, with an anticipated completion date of February...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $122,850 Project Grant on February 15, 2026, to the J. David Gladstone Institutes to support research on microglial control of thalamocortical circuits in Alzheimer's disease (AD). Under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853), this two-year research initiative (through January 31, 2028) will investigate how the TREM2R47H genetic variant affects AD risk by disrupting microglial electrical properties and synaptic remodeling. The research will employ advanced electrophysiological techniques, single-cell transcriptomics, patch-clamp recordings, and optogenetic manipulation across mouse models and human induced pluripotent stem cell (iPSC)-derived microglia cultures to elucidate the mechanisms underlying thalamocortical hypersynchrony in AD. The deliverables from this grant include comprehensive scientific findings spanning three integrated research aims: characterization of how the TREM2R47H variant affects microglial electrical properties and transcriptional states; identification of glutamatergic and GABAergic synaptic mechanisms underlying circuit hypersynchrony; and proof-of-concept therapeutic validation demonstrating whether optogenetic manipulation of microglial membrane voltage can restore synaptic balance and improve behavioral deficits. These research outputs will advance understanding of microglial dysfunction in AD pathogenesis and provide critical mechanistic insights to support development of novel therapeutic strategies for this neurodegenerative disorder affecting nearly five million Americans.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $122.9k | 2/5/26 |