Project Grant K99NS144515
- The National Institute of Neurological Disorders and Stroke awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $1.854 million on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research into compartmentalized reactive oxygen species (ROS) sensing in the brain, specifically investigating how neurons balance mitochondrial energy production with ROS control....
- The National Institute of Neurological Disorders and Stroke awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $2,001,831 on August 20, 2026, to validate [18F]3F4AP PET as a biomarker for peripheral nerve injuries under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds a phased R61/R33 study to develop and validate [18F]3F4AP, a novel PET radioligand, for detecting and quantifying...
- The National Institute of Neurological Disorders and Stroke awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $322,382 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research investigating cell-specific interleukin-1 receptor 1 (IL-1R1) signaling in focal and diffuse traumatic brain injury models. The research uses genetically engineered mice with precise...
- The National Institute of General Medical Sciences awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $443,090 under the Biomedical Research and Research Training program (CFDA 93.859) on September 1, 2026. The award funds a five-year research program investigating the mechanisms of perioperative neurocognitive disorder, a neurotoxic condition arising from anesthesia and surgery that is characterized by declines in memory, attention, and executive...
- Federal Grant Award Summary The Eunice Kennedy Shriver National Institute of Child Health and Human Development awarded a $165,000 Project Grant to Massachusetts General Hospital (The General Hospital Corporation) under the Child Health and Human Development Extramural Research program (CFDA 93.865) for the period August 1, 2025 through July 31, 2027. The research project investigates the cerebrospinal fluid (CSF) system in children with autism spectrum disorder (ASD), with particular focus on...
- The National Institute of Neurological Disorders and Stroke awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $616,126 on August 26, 2026, to conduct in vivo genome editing research for cerebrovascular disorders under NINDS Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). The award funds research defining how and when gene editing can restore cerebrovascular and white matter integrity in an ACTA2 R179H...
- The National Institute of Mental Health awarded Massachusetts General Hospital $824,728 on March 25, 2026, under the Mental Health Research Grants program (CFDA 93.242) to characterize intracortical feedforward and feedback sensory processes in autism spectrum disorder. The award funds a multimodal neuroimaging study examining the hypothesis that autism spectrum disorder involves a fundamental imbalance between bottom-up (feedforward) and top-down (feedback) information flow in sensory cortex....
- The National Institutes of Health Office of the Director awarded The General Hospital Corporation (Massachusetts General Hospital) $783,750 under the Trans-NIH Research Support program (CFDA 93.310) on September 1, 2026, to conduct therapeutic discovery in neurodegeneration using bioengineered organoids and artificial intelligence-driven genomics approaches. The award funds development of multiplexed differentiation strategies to generate midbrain organoids that integrate all major brain cell...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded The General Hospital Corporation (Massachusetts General Hospital) $234,070 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds a five-year mentored patient-oriented research career development program (K23 mechanism) investigating how direct electrical...
- The National Institute of Neurological Disorders and Stroke awarded The General Hospital Corporation (Massachusetts General Hospital) $629,733 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support research into the mechanisms of magnetic activation of neurons. The research combines engineering, electrophysiological recordings, and computational modeling to systematically study how induced electromagnetic fields...
The National Institute of Neurological Disorders and Stroke awarded The General Hospital Corporation (Massachusetts General Hospital) $129,330 under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) on August 6, 2026. The funded research quantifies folate receptor binding potential in the human choroid plexus using MRI-PET imaging. The work addresses a critical gap in understanding cerebral folate transport in autism spectrum disorder, specifically measuring folate receptor alpha (FRA) function in the living human brain. The central hypothesis tests whether elevated FRA autoantibody titers associate with reduced FRA binding potential in the choroid plexus. In the K99 phase, the investigator will establish normative FRA binding variability in healthy adults using [18F]AZAFOL PET-MRI. Performance occurs in Charlestown, Massachusetts, with a period of performance from August 6, 2026 through July 31, 2028. The award is classified as a Project Grant, an assistance type supporting investigator-initiated research. The Extramural Research Programs funding supports basic and translational research exploring brain and nervous system structure and function, with applications addressing neurological disease reduction.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $129.3k | 8/5/26 |