Project Grant R01NS143925
- The National Institute of Mental Health awarded Massachusetts General Hospital $453,750 under the Mental Health Research Grants program (CFDA 93.242) on September 1, 2026, to develop a closed-loop system for assessing target network engagement using concurrent transcranial magnetic stimulation and functional MRI. The recipient is developing a flexible radiofrequency coil array (the RF Cap) that enables functional MRI acquisition simultaneously with transcranial magnetic stimulation in a...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded The General Hospital Corporation (Massachusetts General Hospital) $234,070 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds a five-year mentored patient-oriented research career development program (K23 mechanism) investigating how direct electrical...
- The National Institute of Neurological Disorders and Stroke awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $511,402 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop non-invasive transcutaneous vagus nerve stimulation as a novel neuromodulatory intervention targeting aneurysmal subarachnoid hemorrhage. The project will test whether non-invasive vagus nerve...
- The National Institute of Neurological Disorders and Stroke awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $322,382 on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research investigating cell-specific interleukin-1 receptor 1 (IL-1R1) signaling in focal and diffuse traumatic brain injury models. The research uses genetically engineered mice with precise...
- Federal Grant Award Summary Massachusetts General Hospital received a $165,000 Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) for a two-year project period beginning August 1, 2025 and concluding July 31, 2027. The award supports research focused on modeling and safety assessment of magnetic spinal cord stimulation (MSCS), an...
- The National Institute of Mental Health awarded Trustees of Dartmouth College $114,152 on September 1, 2026, under the Mental Health Research Grants program (CFDA 93.242) to support research determining and enhancing the cellular selectivity of transcranial magnetic stimulation using optical physiology and computational models. The funded research directly tests predictions about how transcranial magnetic stimulation (TMS)—an FDA-approved treatment for drug-resistant depression,...
- The National Institute of Neurological Disorders and Stroke awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $1.854 million on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research into compartmentalized reactive oxygen species (ROS) sensing in the brain, specifically investigating how neurons balance mitochondrial energy production with ROS control....
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $3,565,780 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop a groundbreaking high-frequency trans-spinal magnetic stimulation (HF-TSMS) system for the non-invasive treatment of neuropathic pain. The funded project aims to create an HF-TSMS tool that can target neural pathways involved in...
- The National Institute of Neurological Disorders and Stroke awarded The General Hospital Corporation (doing business as Massachusetts General Hospital) $616,126 on August 26, 2026, to conduct in vivo genome editing research for cerebrovascular disorders under NINDS Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853). The award funds research defining how and when gene editing can restore cerebrovascular and white matter integrity in an ACTA2 R179H...
- The National Institute of Neurological Disorders and Stroke awarded Massachusetts Institute of Technology $651,069 on May 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop spatially multiplexed imaging techniques for visualizing complex signaling networks in neurons and brain cells. The research advances a method called Signaling Reporter Islands (SIRIs) that enables simultaneous imaging of multiple cellular signals...
The National Institute of Neurological Disorders and Stroke awarded The General Hospital Corporation (Massachusetts General Hospital) $629,733 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support research into the mechanisms of magnetic activation of neurons. The research combines engineering, electrophysiological recordings, and computational modeling to systematically study how induced electromagnetic fields activate individual neurons. The work addresses fundamental biophysical questions about magnetic stimulation—specifically, the roles of field strength, longitudinal gradient, transverse gradient, and intracellular induction in neuronal activation. The project builds on the advantages of coil-based magnetic stimulation over conventional electrical stimulation, including enhanced spatial precision and reduced adverse tissue reactions, with applications in transcranial magnetic stimulation (TMS) for clinical use and smaller coils for next-generation neural implants such as visual and cochlear prostheses. The research team has developed small coils ranging from 0.1 to 10.0 millimeters in diameter integrated into a physiology rig that captures neuronal responses. Addressing the current limitation that only 30–40 percent of TMS users realize long-term benefits, the work aims to improve the efficacy and reliability of magnetic stimulation for both clinical and implantable applications. Performance occurs in Boston, Massachusetts, with a period of performance from August 15, 2026, through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $629.7k | 8/14/26 |