Project Grant K99NS144382
- This $576,142 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research conducted by Oregon Health & Science University (OHSU) to enhance understanding of oligodendrocyte (OL) development and myelination in the central nervous system. The key objectives of the 5-year project are to: Define the cellular mechanisms by which the...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded Kenyon College a Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $454,424 grant, effective April 1, 2025 through March 31, 2028, aims to characterize the cellular and molecular mechanisms of Schwann cell demyelination and identify factors that promote peripheral remyelination using a novel larval zebrafish model. The project will test...
- This $614,009 federal Project Grant award was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research into the molecular mechanisms of oligodendrocyte myelination and remyelination, which are critical processes for addressing demyelinating diseases of the central nervous system like multiple sclerosis. The awardee, Children's Hospital...
- This federal Project Grant award of $440,275.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to systematically discover upstream regulators of the OLIG2 transcription factor, which plays a central role in central nervous system myelination by oligodendrocytes. The award aims to identify enhancers and transcription factors that regulate OLIG2...
- This Project Grant award, totaling $429,000.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The award will fund research at Oregon Health & Science University (OHSU) to investigate the fundamental interactions between astrocytes and oligodendrocytes, two major types of glial cells in the central nervous system, and how these...
- This federal Project Grant award of $458,189 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award supports research focused on understanding how specific membrane-remodeling factors regulate oligodendrocyte membrane dynamics and myelination in the central nervous system. The research aims to elucidate the mechanisms by which these factors shape...
- This $536,617 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research conducted by Oregon Health & Science University (OHSU) to understand the mechanisms of adult neural regeneration using planarian and zebrafish model organisms. The research aims to elucidate how adult stem cells can generate the appropriate diversity of...
- This Project Grant award of $420,744 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, supports research by Oregon Health & Science University to profile adenosine to inosine editing in single neurons. The project aims to understand how this post-transcriptional RNA modification, which is prevalent in the developing nervous system, varies...
- This Project Grant award of $637,820 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to identify novel genes responsible for proper cortical development, lamination, and axonal trajectories, as well as genes controlling the internal capsule and corticospinal tract in mice. The research will leverage forward genetics in mice to uncover new fundamental...
- This federal Project Grant award of $451,822 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research by Oregon Health & Science University to study the distinct molecular profiles and functions of "pioneer" and "follower" neurons during nervous system development. The project aims to determine the specific transcriptional profiles that...
This $126,122 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research at Oregon Health & Science University (OHSU) to elucidate the role of the protein CCNYL1 in oligodendrocyte differentiation and myelination. The project aims to define CCNYL1's function in oligodendrogenesis using zebrafish and mouse models, investigate related signaling pathways like Wnt, and determine CCNYL1's influence on experience-dependent myelination and remyelination in adult mice. This research employs advanced techniques such as in vivo imaging, CRISPR gene editing, proteomics, and behavioral studies to uncover novel molecular mechanisms controlling oligodendrocyte formation - insights that may support the development of targeted therapies for demyelinating diseases like multiple sclerosis.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $126.1k | 8/6/25 |