Project Grant K99NS140628
- The $258,342 Project Grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke will support research into the mechanisms of dendritic tiling at Stanford University. Specifically, the grant will fund two specific aims: first, to test the hypothesis that activity-dependent mechanisms result in tiling of dendrites in C. elegans using live imaging of neighboring neurons labeled with distinct fluorescent reporters; and second, to assess the impact of...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $110,577 to The Regents of the University of Colorado, doing business as the University of Colorado-Denver, to investigate the mechanisms and impact of amyloid-beta mediated disruption of synaptic nanoarchitecture. The research aims to thoroughly characterize the kinetics and...
- This Project Grant award, valued at $481,250.00 and provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop a synthetic biological system to manipulate subcellular RNAs and proteins in growth cones or synapses of subtype- and context-specific neurons. The goal is to enable unique forms of subcellular functional investigation in subtype- and...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to investigate the role of inhibitory synaptic nanostructure in inhibitory synaptic plasticity. The total award amount is $110,574.00 and the period of performance is from July 14, 2025 to November 30, 2027. The research will be conducted by the University of Colorado-Denver,...
- The National Institute of Neurological Disorders and Stroke (NINDS), part of the U.S. Department of Health and Human Services, awarded a $663,942 Project Grant to Yale University under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program. The grant, awarded on July 25, 2025 with an ultimate completion date of June 30, 2030, supports research to examine the interplay between the synaptic proteins complexin and synaptotagmin and their...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $551,250 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of California, Los Angeles (UCLA) to support research focused on understanding the molecular mechanisms underlying the formation of synaptic connections between neurons in the brain. The key research aims are to uncover the molecular basis of synaptic specificity in the...
- This federal Project Grant award of $660,632 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research aimed at understanding the structure and dynamics of the fusion pore, a critical component of the membrane fusion process that underlies neuronal function. The key objectives of the research are to: 1) leverage a novel reconstituted system to...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $385,500 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Leland Stanford Junior University (Stanford University). This 2-year grant, effective February 1, 2025, will support the development of an inducible and multiplexed dual gene modulation CRISPR system to study neuronal activity and regeneration. The goal is to create a synthetic biology...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate learning-induced synaptic plasticity in corticospinal output neurons of the motor cortex. The $221,448 award to the University of California, San Diego (UCSD) will fund two specific aims: 1) simultaneously measuring synaptic and spiking...
- This $217,701 federal Project Grant award from the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049) aims to elucidate the role of liquid-liquid phase separation (LLPS) in the pathological aggregation of proteins associated with neurodegenerative diseases. The research, conducted by a multi-disciplinary US-France consortium, will employ computational and experimental techniques to gain novel insights into the protein conformations and...
This federal Project Grant award, titled "The Phase Separation of Neuronal Pentraxins: From Synapse Formation to Plasticity", was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The $122,526 award supports research at Stanford University to explore a novel mechanism involving liquid-liquid phase separation of neuronal pentraxins and their role in regulating synapse formation and synaptic plasticity. The project aims to use mouse genetics, super-resolution imaging, biochemical reconstitution, structural biology, and proximity labeling to elucidate how neuronal pentraxin-based cell adhesions coordinate synaptic structural changes and AMPA receptor clustering during synaptogenesis and long-term potentiation. This research has the potential to deepen understanding of how protein phase separation at the synaptic cleft regulates synapse assembly and function, which is crucial given the link between disruptions in these processes and various neurological and psychiatric disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $122.5k | 8/6/25 |