Project Grant K99HL188909
- The National Heart, Lung, and Blood Institute awarded the University of Illinois $2,386,712 on September 23, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the molecular mechanisms by which endotoxin exposure protects against allergic asthma through MIZ1-mediated epigenetic regulation and to evaluate the therapeutic potential of targeting the MIZ1 pathway. The research will pursue three specific aims: investigation of how endotoxin downregulates MIZ1 and...
- The National Heart, Lung, and Blood Institute awarded the University of Pennsylvania $177,822 on August 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to identify strategies for improving allergen mitigation among adults with persistent asthma to decrease disease morbidity. The award funds career development for a candidate investigator conducting qualitative research and implementation science to address three primary aims: determining barriers and facilitators to...
- The National Heart, Lung, and Blood Institute awarded the University of Illinois $346,960 under the Cardiovascular Diseases Research program (CFDA 93.837) on September 20, 2025, to investigate the inflammatory-fibrotic axis in advanced pulmonary sarcoidosis-related fibrosis (APSF). The research applies single-cell RNA sequencing (scRNA-seq) and surface protein indexing to identify key regulators and signaling pathways within CD14+ monocyte subpopulations in individuals with chronic...
- The National Heart Lung and Blood Institute awarded Northwestern University $104,928 for a Project Grant (K99HL188111) on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837). The award funds research targeting lipid signaling pathways in perivascular interstitial macrophages as a therapeutic strategy for pulmonary fibrosis. The investigator will use single-cell spatial transcriptomics and RNA sequencing to characterize how perivascular interstitial macrophages...
- The National Heart, Lung, and Blood Institute awarded Brigham & Women's Hospital Inc. a K24 Project Grant totaling $266,442 on September 15, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837). The award funds research and mentorship activities on mechanisms of airway inflammation and remodeling in chronic rhinosinusitis and asthma. The research plan tests three epithelial-centric hypotheses: epithelial metabolic reprogramming in chronic rhinosinusitis with nasal polyps...
- The National Heart, Lung, and Blood Institute awarded The Regents of the University of California, San Francisco $3,205,321 on August 20, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the genetic and molecular mechanisms of prostaglandin E2 (PGE2)-EP4-induced goblet cell metaplasia in asthma. The project combines biophysical, cellular, molecular, and genetic analyses to determine how EP4 receptor activation promotes goblet cell hyperplasia in airway...
- The National Heart, Lung, and Blood Institute awarded The Regents of the University of California, San Francisco $174,744 on June 2, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of the phosphatase SHP1 in modulating acute lung injury and acute respiratory distress syndrome. The research focuses on SHP1-dependent regulation of neutrophil activation and its protective effects against hyperinflammation and pulmonary hemorrhage in acute lung...
- Federal Project Grant Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded $161,935 to the University of Pittsburgh on September 1, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to support a five-year mentored clinical scientist research career development initiative. Under the direction of Dr. Kristina Gaietto, an instructor of pediatrics at Children's Hospital of Pittsburgh, this project will deliver research products focused on improving diagnostic...
- The National Institutes of Health National Heart Lung and Blood Institute awarded Vanderbilt University Medical Center $341,280 on September 19, 2025, under the Cardiovascular Diseases Research program (CFDA 93.837) to support a five-year mentored career development project investigating apoptosis resistance mechanisms in pulmonary arterial smooth muscle cells. Dr. Niedermeyer, under mentorship from Dr. Larissa Shimoda and Dr. Mahendra Damarla, will conduct hands-on laboratory research, complete...
- The National Heart, Lung, and Blood Institute awarded the University of Illinois $174,560 on June 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate mechanisms underlying the immune paradox in sarcoidosis. The award funds research into the dysregulated immune response in sarcoidosis, a rare disease characterized by genetic predisposition and granulomatous inflammation. The project examines the paradoxical presentation of peripheral lymphopenia alongside...
The National Heart, Lung, and Blood Institute awarded The University of Chicago $127,253 on September 1, 2026, under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate protein palmitoylation in asthma pathogenesis and treatment. Dr. Salamone will use cell and animal models to test the hypothesis that dysregulated protein palmitoylation modulates airway epithelial and T cell function. In the mentored K99 phase, she will evaluate palmitoylation in epithelial cells by investigating JAK/STAT signaling in asthmatic epithelial cells (Aim 1) and conducting an unbiased proteomics screen to identify palmitoylated proteins affecting epithelial barrier integrity (Aim 2). As she transitions to the independent R00 phase, she will investigate palmitoylation in T cells using transgenic mouse lines and an allergic sensitization model of asthma to distinguish the contributions of dysfunctional palmitoylation in epithelia versus T cells. The award is structured as a Project Grant, a training and early-career development mechanism. Performance occurs in Chicago, Illinois, with a period of performance from September 1, 2026, through May 31, 2028. This K99/R00 award supports career transition of a postdoctoral investigator toward an independent research career in cardiovascular and pulmonary research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $127.3k | 8/10/26 |