Project Grant K08HL177170
- This $1,392,946 Project Grant awarded on July 20, 2025 by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support research at the University of Pittsburgh to investigate the role of microbial-derived metabolites in driving airway hyperresponsiveness in obesity-associated asthma. The project aims to elucidate how dysregulated bile acid metabolism and gut dysbiosis instigate obesity-related asthma through alterations in the unfolded protein...
- This Project Grant award, provided by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research), aims to support a mentored implementation science research program focused on improving asthma care and outcomes for children from marginalized communities. The $120,363 award, effective August 18, 2025, will fund Dr. Michelle Eakin's efforts to expand her mentoring program in patient-oriented implementation science. The project will leverage ongoing data collection...
- The federal Project Grant award of $156,899.00 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to identify distinct clinical phenotypes of pediatric status asthmaticus and evaluate the effects of adjunctive asthma treatments like magnesium and aminophylline across those phenotypes. The primary awardee, Trustees of Indiana University - Indianapolis, will conduct this research over a period from July 2025 to June 2030. The...
- This Project Grant award of $154,980 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at Seattle Children's Hospital to investigate circadian regulation of epithelial immune responses in asthma. The key activities include: Measuring viral replication and innate immune responses in airway epithelial cell cultures from healthy donors and pediatric asthma patients in relation to cellular circadian time. Comparing circadian gene...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $180,174 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Children's Hospital of Philadelphia Research Institute. The grant will fund a study to develop a framework for designing the next generation of pediatric acute respiratory distress syndrome (ARDS) clinical trials. Key objectives include: 1) Comparing heterogeneity of treatment effect (HTE) analysis methodologies in a trial of pediatric...
- The National Heart, Lung, and Blood Institute (NHLBI), a division of the National Institutes of Health (NIH), awarded a $189,000 Project Grant under CFDA #93.837 Cardiovascular Diseases Research program to the University of Colorado-Denver. The 2-year grant, with a period of performance from September 15, 2025 to August 31, 2027, will support research to investigate the role of outdoor air pollution and environmental allergens in driving treatment response in children with acute asthma...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $288,986 to Biotherapeutics, Inc., a biotechnology company in Blacksburg, VA. The grant supports the development of a novel oral immunoregulatory therapeutic for the treatment of asthma. The key objectives are to: 1) Determine the safety profile and pharmacokinetics of the new therapeutic in rats, and 2) Characterize the therapeutic...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $246,000.00 to the University of Chicago to conduct research focused on understanding how the "farm effect" and early-life exposure to barn animals and microbes impacts the immune system and susceptibility to childhood asthma. The key products to be delivered through this 2-year project include: 1) a comprehensive characterization of the transcriptional...
- The federal Project Grant award of $732,225 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research on "Mitochondrial Mechanisms in Asthma" at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. This multi-year (2025-2029) project aims to investigate how variations in the mitochondrial genome influence asthma risk and pathophysiology through alterations in mitochondrial bioenergetics and...
- This $186,896 Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will fund a study by the Regents of the University of California, San Francisco (UCSF) to examine the impact of adverse childhood experiences (ACEs) screening and behavioral-social support on asthma and chronic obstructive pulmonary disease (COPD) health outcomes. The study aims to leverage data from LADHS' implementation of ACEs screening to 1) analyze the...
This federal Project Grant award, titled "T-HELPER 2-LOW PEDIATRIC ASTHMA ENDOTYPES: OMICS, BIOMARKERS, AND CLINICAL CHARACTERISTICS", was provided by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research). The $161,935 grant supports a 5-year research career development plan led by Dr. Kristina Gaietto at the University of Pittsburgh Medical Center Children's Hospital of Pittsburgh. The project aims to 1) identify serum protein biomarkers for T2-low asthma endotypes in children, 2) examine associations between exposure to violence/violence-related distress and the T17-high endotype, and 3) assess changes in endotype profiles over 6-12 months and associated factors. The research leverages existing biospecimens from previous pediatric asthma studies and will recruit a pilot cohort of 30 children. This work seeks to improve diagnostic methods and elucidate pathogenic mechanisms of T2-low asthma endotypes, which comprise over half of childhood asthma cases but lack targeted treatments compared to T2-high asthma.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $161.9k | 8/29/25 |