Project Grant R01HL181375
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $760,759 to the University of Illinois to examine the immunoregulatory role of a specific dendritic cell subset, CX3CR1+CDC2, in allergic lung inflammation. The project aims to characterize the anti-inflammatory functions of this cell population and its impact on regulatory T cell development and the resolution of allergic asthma symptoms. Through the use of novel...
- This $387,116 Project Grant award from the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) supports research at the University of South Florida to investigate the sensory neuronal mechanisms underlying the development of house dust mite-induced airway hyperreactivity, a key characteristic of asthma. The long-term goal is to define the neural mechanisms triggered by house dust mite exposure that lead to the development of airway...
- The federal Project Grant award, titled "MicroRNAs in Airway Smooth Muscle Function and Asthma," was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837). The $616,814 award, with a start date of January 15, 2025 and a completion date of November 30, 2028, supports research at the President and Fellows of Harvard College (Harvard T.H. Chan School of Public Health) to investigate the role of microRNAs in regulating...
- This $680,562 federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research investigating the long-term lung epithelial alterations resulting from early-life respiratory syncytial virus (RSV) infection. The research aims to determine the mechanisms by which early-life RSV infection predisposes individuals to developing asthma later in life, focusing on the role of innate cytokines like IL-1β and IL-33 in driving...
- This $1,392,946 Project Grant awarded on July 20, 2025 by the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will support research at the University of Pittsburgh to investigate the role of microbial-derived metabolites in driving airway hyperresponsiveness in obesity-associated asthma. The project aims to elucidate how dysregulated bile acid metabolism and gut dysbiosis instigate obesity-related asthma through alterations in the unfolded protein...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate how early-life inflammation and viral infections shape the development and function of type 2 innate lymphoid cells (ILC2s) in the lungs, and their role in driving childhood asthma susceptibility. The $740,709 award to the University of Utah is intended to define the cellular and molecular mechanisms by...
- This $2,456,717 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to exploit emerging ideas in G protein-coupled receptor biology and pharmacology to treat asthma. The award supports a highly collaborative research team at Thomas Jefferson University's Sidney Kimmel Medical College to pursue three key goals: 1) identify novel targets and targeting molecules involving G protein-coupled receptor...
- This Project Grant award of $796,189.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research at the University of Illinois to define the dynamics of neutrophil subpopulations and their role in inflammatory lung injury and repair. The study aims to identify the distinct functions of the CXCR2 and CXCR4 chemokine receptors in regulating neutrophil trafficking and activation during acute lung inflammation, with the goal of developing...
- The federal Project Grant award of $732,225 from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research on "Mitochondrial Mechanisms in Asthma" at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University. This multi-year (2025-2029) project aims to investigate how variations in the mitochondrial genome influence asthma risk and pathophysiology through alterations in mitochondrial bioenergetics and...
- The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research federal grant program (CFDA 93.837), awarded a $702,308 project grant to the University of Colorado-Denver for a study titled "Function and Regulation of Airway Mucin Glycosylation". The project, with a performance period from September 1, 2025 to June 30, 2029, aims to investigate the role of mucin glycosylation, specifically the enzyme fucosyltransferase 2 (FUT2), in regulating mucus...
This federal Project Grant award, valued at $801,648.00, was provided by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) to the University of Illinois in Chicago. The grant aims to uncover the molecular mechanisms responsible for the protective effects of early endotoxin exposure against asthma. The key objectives are to investigate the role of the MIZ1 protein in mediating the protective effects of endotoxin against allergic asthma, determine the underlying mechanisms, and evaluate the therapeutic potential of targeting the MIZ1 pathway. The research will be conducted through three specific aims: 1) examining the mechanisms of MIZ1 downregulation by endotoxin and its role in protecting against asthma, 2) elucidating how endotoxin-induced MIZ1 downregulation confers asthma protection, and 3) evaluating the therapeutic efficacy of targeting the MIZ1 pathway in an asthma model and analyzing MIZ1 pathway components in human asthmatic patients. The grant has an award date of September 23, 2025 and an ultimate completion date of May 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $801.6k | 9/22/25 |