Project Grant K99HL186014
- Federal Grant Award Summary Yale University received a $147,486 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded on July 15, 2025, with a completion date of June 30, 2028. The grant supports research to define the role of G3BP1, an RNA binding protein (RBP), in vascular development and blood vessel formation. The research will utilize a novel G3BP1 loss-of-function mutant zebrafish model to...
- Federal Project Grant Award Summary Yale University received a $958,850 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with a completion date of May 31, 2029. This research project focuses on investigating interleukin-1 (IL-1) signaling mechanisms in critically ill children with bronchiolitis to identify disease severity markers and develop therapeutic interventions. The...
- Federal Project Grant Award Summary Yale University received a $671,373 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective July 1, 2026, through March 31, 2030. The award funds research investigating ferroptosis regulation in lung inflammation and injury, with the primary deliverable being scientific findings on the mechanisms by which pulmonary inflammation damages alveolar cells. The project...
- Federal Project Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Connecticut Health Center a $130,275 Project Grant (CFDA 93.837 – Cardiovascular Diseases Research) effective April 1, 2026, through March 31, 2028. The research project investigates the role of TRPM7-mediated signaling in vascular remodeling and abdominal aortic aneurysm (AAA) pathogenesis. The study addresses a critical clinical gap, as AAA affects 1–2% of the elderly...
- Grant Summary Yale University received a $756,224 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded August 15, 2025, with performance through June 30, 2029. The grant funds research investigating heterochromatin dynamics and epigenetic regulation in vascular smooth muscle (SMC) plasticity. The research aims to elucidate how SUV39H1 histone methyltransferase and H3K9me3 epigenetic marks control...
- Federal Grant Award Summary Yale University received a $1.498 million Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 23, 2025, with a completion date of August 31, 2027. The award funds research investigating the molecular mechanisms of sex differences in scleroderma-associated interstitial lung disease (SSc-ILD), specifically examining the role of mitochondrial DNA (mtDNA) and Toll-like...
- Federal Grant Award Summary Yale University received a $706,573 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, through May 31, 2029. The award supports the development of novel statistical methodologies for analyzing multiple and composite outcomes in cluster-randomized trials (CRTs) using win estimands (net benefit, win ratio, win odds). The project will create a suite of...
- Federal Project Grant Award Summary Yale University received a $1.68M Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded July 1, 2026, with completion targeted for April 30, 2028. The award funds basic science research investigating the developmental cellular and molecular mechanisms underlying Circle of Willis (CW) formation and maintenance—a critical collateral circulatory system in the brain that...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded The Leland Stanford Junior University a $2.44 million Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) on August 15, 2025, with a completion date of July 31, 2030. This five-year award supports research to identify causal gene programs that influence vascular diseases, specifically coronary artery disease and pulmonary arterial hypertension. The project will deliver advanced...
- Federal Grant Award Summary The National Heart, Lung, and Blood Institute (NHLBI) awarded the University of Alabama at Birmingham a Project Grant of $535,556 under the Cardiovascular Diseases Research program (CFDA 93.837) effective August 1, 2025, with completion targeted for May 31, 2030. This award supports research to elucidate the role of a novel mechanosensitive histone modification (H3T32 O-GlcNAc) in atherosclerosis pathogenesis. The research investigates how atheroprone shear stress...
The National Heart, Lung, and Blood Institute (NHLBI) awarded Yale University a Project Grant of $126,177 under the Cardiovascular Diseases Research program (CFDA 93.837) to investigate the role of primary cilia protein Intraflagellar Transport 88 (IFT88) in smooth muscle cell phenotype and vascular remodeling. The grant, awarded June 17, 2026, with completion scheduled for April 30, 2028, supports research aimed at addressing a significant gap in understanding how smooth muscle cells regulate their phenotype during vascular disease progression, including conditions such as atherosclerosis, aneurysm, and coronary artery disease. The project deliverables consist of research services conducted at Yale University's New Haven facility examining mechanotransduction processes, intimal hyperplasia pathogenesis, and arteriovenous fistula maturation. The research will advance knowledge of how primary cilia function in smooth muscle cells and provide insights applicable to polycystic kidney disease, an IFT88 loss-of-function condition affecting dialysis patients requiring surgical vascular interventions. This investigation contributes to the NHLBI's broader mission of fostering basic and translational cardiovascular science research to prevent and treat heart and blood diseases.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $126.2k | 6/19/26 |