This $647,359 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports the engineering of biomaterials with controlled biomolecule delivery for cardiovascular applications. The key products and services to be delivered include: Efficient and sustainable delivery of microRNA-145 from a novel biomaterial (PVA-CDI immobilized aminated fucoidan, or PCAF) to smooth muscle cells to induce a contractile...
This Project Grant award of $726,205 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports the development and validation of a new Super-Resolution Intravascular Ultrasound (SR-IVUS) technology. The goal is to enable effective imaging of the vasa vasorum network and thin fibrous cap of vulnerable atherosclerotic plaques, which are major contributors to acute coronary syndromes. The award funds the development of a dual-mode SR-IVUS catheter...
The National Heart, Lung, and Blood Institute (NHLBI) awarded Unandup, LLC a $413,595 Project Grant under the Cardiovascular Diseases Research (CFDA 93.837) program. The grant will fund the development of a Magnetic Rotational Platform for Coronary Lesions, an innovative medical device technology designed to improve percutaneous coronary intervention (PCI) procedures. Unandup's platform leverages magnetic fields to enable safer and more effective rotational atherectomy compared to current...
This $437,461 federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), funded under the Cardiovascular Diseases Research program (CFDA 93.837), supports the development of a novel stabilization catheter device for His pacing lead implantation. The goal is to improve the accuracy and ease of His bundle pacing, an emerging alternative cardiac resynchronization therapy (CRT) for heart failure patients. The project aims to refine a deployable suction-tipped lead...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $595,464 to Cerulean Scientific Inc. to develop and evaluate a tethered liquid perfluorocarbon (TLP) coating for peripheral vascular grafts. The TLP coating aims to prevent thrombosis, biofilm formation, and other complications that contribute to the high failure rates of these medical devices. The 18-month project will involve in vitro...
This $580,863 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Program (CFDA 93.837), supports research to develop improved cardiac regenerative therapies using engineered human cardiac organoids. The key products and services being delivered include: Optimizing the electrical properties and surface roughness of silicon nanowires incorporated into the cardiac organoids to enhance their interaction with human pluripotent stem...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $366,006 Project Grant (CFDA 93.286 - Discovery and Applied Research for Technological Innovations to Improve Human Health) to the Georgia Tech Research Corporation to develop flexible piezo film intravascular ultrasound (IVUS) arrays on guidewires and catheters. The goal is to integrate IVUS imaging capability onto standard guidewires and catheters used in over 1 million percutaneous coronary and peripheral...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), aims to develop a flexible bioelectronic microarchitecture that integrates a capillary-like delivery network and a tissue-like sensing network to improve cardiac tissue engineering. The $488,026 award supports the creation of a system that can efficiently deliver media and provide real-time physiological feedback to enhance the development of...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $769,789 to The Leland Stanford Junior University to develop a catheter-injectable, engineered biomaterial for sustained delivery of the protein therapy neuregulin-1 (NRG1) to the myocardium for the treatment of myocardial infarction (MI). The key objectives are to: 1) Evaluate a novel crosslinked hydrogel formulation (HA-LINC) that...
This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $1,283,558 to Massachusetts Institute of Technology (MIT) to develop a breakthrough innovation in electrophysiological monitoring of cardiomyocyte networks. The key products and services to be delivered under this 4-year award include: 1) Developing a scalable nanofabrication process to manufacture multi-electroplasmonic nanoantenna...