This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837) provides $580,863 to Clemson University to develop improved engineered cardiac organoids for heart repair. The key products and services include: Optimizing the surface roughness of electrically conductive silicon nanowires (e-SiNWs) to enhance their interactions with human pluripotent stem cell-derived cardiomyocytes (HPSC-CMs) within the cardiac organoids. Additionally, the project will use a PHD2 inhibitor to improve prevascularization and cell survival of the organoids when implanted in ischemia/reperfusion (I/R) injured hearts. The goal is to determine the minimal effective dose of the optimized, prevascularized nanowired organoids to achieve near-full functional recovery in a rat I/R injury model, which will then be validated in a porcine model. Sub-awards support the project's animal studies, with collaborators from the Medical University of South Carolina and the University of Chicago providing expertise in cardiovascular research, large animal models, and silicon nanowire fabrication. The award period is from Dec 23, 2024 to Nov 30, 2028.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $580.9k | 12/22/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
28292092017695S | University Of Chicago | Project Grant R01HL173532 | $31.8k | 12/23/24 | |
28282092017695S | The Medical University Of South Carolina | Project Grant R01HL173532 | $163.7k | 12/23/24 |