Project Grant R01HL173532

Award Date 12/23/24
Completion Date 11/30/28
Dollars Obligated $581K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Clemson, SC 29634, USA
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Optimizing the surface roughness of electrically conductive silicon nanowires (e-SiNWs) to enhance their interactions with human pluripotent stem cell-derived cardiomyocytes (HPSC-CMs) within the cardiac organoids. Additionally, the project will use a PHD2 inhibitor to improve prevascularization and cell survival of the organoids when implanted in ischemia/reperfusion (I/R) injured hearts. The goal is to determine the minimal effective dose of the optimized, prevascularized nanowired organoids to achieve near-full functional recovery in a rat I/R injury model, which will then be validated in a porcine model.

Sub-awards support the project's animal studies, with collaborators from the Medical University of South Carolina and the University of Chicago providing expertise in cardiovascular research, large animal models, and silicon nanowire fabrication. The award period is from Dec 23, 2024 to Nov 30, 2028.

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