Project Grant K99HD122257
- Federal Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded The Washington University a Project Grant of $619,913 under the Child Health and Human Development Extramural Research program (CFDA 93.865) effective May 15, 2026, through March 31, 2031. The funded research project, titled "Temperature and Polyamines: Their Roles in CatSper Regulation and Sperm Fertility," investigates the mechanisms regulating the sperm-specific calcium channel...
- Federal Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded The Washington University $427,625 under the Child Health and Human Development Extramural Research program (CFDA 93.865) for a project grant titled "Retinoic Acid Signaling and Uterine Epithelial Cell Fate." The award, issued May 15, 2026, with completion targeted for May 31, 2028, supports investigator-initiated biomedical research to advance understanding of reproductive tract...
- Federal Project Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded a $427,625 Project Grant to Washington University's Office of Sponsored Research Services on August 6, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports a two-year research initiative (completion date: July 31, 2027) investigating the consequences of postpartum exogenous oxytocin administration on maternal-neonatal...
- Federal Project Grant Summary The National Institute of Child Health and Human Development (NICHD) awarded The Washington University a $657,377 Project Grant effective September 1, 2025, through May 31, 2030, under the Child Health and Human Development Extramural Research program (CFDA 93.865). This award funds research to advance understanding of human trophoblast development and function using pluripotent stem cell models. The research addresses critical gaps in knowledge regarding...
- Federal Project Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded a $107,574 Project Grant to The Washington University, Office of Sponsored Research Services, effective September 1, 2025, through August 31, 2028, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The research project, titled "Functional Effects of Oxytocin Receptor Post-Translational Modifications," addresses critical gaps in...
- Federal Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded The Washington University a $248,994 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective August 1, 2025, through July 3, 2028. This award supports investigator-initiated research to elucidate the mechanisms of de novo germline histone mutations underlying developmental disorders. The project integrates biochemical and genomic...
- Federal Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded The Washington University a $1,999,186 Project Grant effective September 1, 2025, through August 31, 2027, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award supports "Quantitative and Computational Characterization of Oxytocin Receptor Function," research designed to address clinical variability in oxytocin dosing for labor induction...
- Federal Project Grant Award Summary Yale University received a $2.25 million Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct research on the genetic, cellular, and molecular mechanisms underlying reduced sperm motility in male infertility. The award, issued on August 8, 2025, with a completion date of April 30, 2030, will support investigator-initiated...
- Federal Grant Award Summary The University of Virginia received a $962,892 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective July 30, 2025, through April 30, 2030. This research initiative investigates membrane protein-mediated signaling as a driver of spermiogenesis, specifically examining the role of the transmembrane channel-like protein 5 (TMC5) in...
- Federal Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded a $163,050 Project Grant to the University of Chicago on November 22, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award extends through June 30, 2029, and supports a research initiative titled "Leveraging Enhanced Phenotyping and Causal Inference Approaches to Investigate the Effect of Maternal Medication Exposures on Child...
The National Institute of Child Health and Human Development (NICHD) awarded The Washington University a Project Grant of $125,142 under the Child Health and Human Development Extramural Research program (CFDA 93.865) effective June 1, 2026, through May 31, 2028. This award funds research investigating the impact of bacterial vaginosis (BV) toxins on sperm function and fertility. The research will elucidate the molecular mechanisms by which BV-associated toxins, specifically lipopolysaccharide (LPS) from Prevotella and vaginolysin (VLY) from Gardnerella, impair sperm capacitation and fertilizing capacity through dysregulation of calcium signaling in both mouse and human sperm models. The research deliverables include mechanistic studies examining how LPS and VLY induce calcium influx through specific signaling pathways (TLR4 receptor and TRPV4 calcium channel), determination of in vivo consequences of BV toxins on fertility outcomes, and characterization of how these toxins disrupt sperm hyperactivation and acrosomal exocytosis. By advancing understanding of BV-induced sperm dysfunction, this work addresses a significant reproductive health gap, as approximately 37.4% of women with unexplained infertility are diagnosed with BV, yet the underlying mechanisms remain poorly understood. The research aligns with NICHD's 2025 mission to improve reproductive health outcomes.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.1k | 5/19/26 |