Project Grant K99HD120648
- The National Institute of Child Health and Human Development, part of the Department of Health and Human Services National Institutes of Health, awarded $440,000 to the University of Texas Medical Branch at Galveston on August 15, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award funds research to evaluate mechanistic pathways through which heat exposure during pregnancy triggers preterm birth, addressing a knowledge gap in understanding...
- The National Institute of Child Health and Human Development awarded the University of California, San Diego $440,000 on July 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to characterize brainstem noradrenergic circuits controlling reproductive function. The research investigates how chronic psychosocial stress impairs reproductive capacity through inhibition of hypothalamic kisspeptin neuron function, which leads to reduced luteinizing...
- The National Institute of Child Health and Human Development awarded Beth Israel Deaconess Medical Center, Inc. $129,377 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate relationships between sexual behavior rhythms, core body temperature, and sleep in female mice and their implications for fertility. The research will identify brain circuits regulating female sexual behavior rhythms, determine whether mild cooling...
- The National Institute of Child Health and Human Development awarded University of California, San Diego $440,000 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate uterine neuronal innervation dynamics and immune function during the peripartum period. The research maps sympathetic, parasympathetic, and sensory neuronal subtypes across uterine layers in mice, describing their spatial and temporal distribution with proteomic...
- The National Institute of Child Health and Human Development awarded the University of California, San Diego $650,472 on September 1, 2026, under the Child Health and Human Development Extramural Research Program (CFDA 93.865) to investigate how adrenergic signaling from brainstem norepinephrine neurons regulates reproductive neuroendocrine circuits in response to chronic psychosocial stress. The research addresses how stress impairs kisspeptin neuron function and downstream luteinizing...
- The National Institute of Child Health and Human Development awarded New York University $237,660 on January 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to investigate how sickness disrupts maternal brain circuits and caregiving behavior during the postpartum period. The research examines how acute inflammatory challenge—induced by lipopolysaccharide injection—alters neuropeptidergic circuits in the paraventricular nucleus of the...
- The National Institute of Child Health and Human Development awarded California Institute of Technology $128,331 on September 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865) to investigate the hydraulic regulation of human gastrulation and mesodermal patterning using stem cells. The research employs a novel three-dimensional stem cell-based model termed "lumenoids" to dissect mechanobiological principles underlying early...
- The National Institute of Child Health and Human Development awarded The Regents of the University of California, San Francisco $123,147 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award funds research investigating granulosa-derived RNAs as targets for oocyte rejuvenation and age-related oocyte quality infertility. The project comprises three aims: interrogating the mechanism by which RNAs transfer from granulosa cells to...
- The National Institute of Child Health and Human Development awarded New York University $245,782 on February 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to establish a cohort of 90 high-risk pregnancies and investigate how maternal immune activation alters fetal and infant brain development across the birth transition period. The research integrates advanced neuroimaging, maternal inflammatory biomarkers, and objective infant behavioral...
- The National Institute of Child Health and Human Development awarded the University of South Florida $114,237 on June 5, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct research dissecting estrogen receptor alpha (ERA) functions in anteroventral and periventricular medial preoptic area neurons co-expressing the long-form leptin receptor. The research examines how ERA signaling as a nuclear receptor and mRNA-binding protein—distinct from...
The National Institute of Child Health and Human Development awarded the University of California, Los Angeles $123,876 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support a K99/R00 career-development project grant investigating the neural basis of thermoregulatory adaptations during pregnancy. The award funds a candidate's specialized training in miniaturized microscopy to monitor calcium activity of individual neurons in the medial preoptic area (MPO) throughout pregnancy, conducted under the supervision of Drs. Avishek Adhikari and Weizhe Hong at UCLA. During the K99 phase, the research tests whether MPO estrogen receptor-expressing neurons exhibit increased neural activity during pregnancy and whether this activity is required to lower core body temperature in pregnant mice. Gestation length and pup development will be compared between control and experimental groups. During the subsequent R00 independent phase, the work will focus on understanding mechanisms underlying enhanced thermoregulation in pregnant mammals, including humans, testing whether estrogen-sensitive MPO neurons encode heat exposure and mediate protective cooling mechanisms that safeguard fetal development. Pup health outcomes will be compared in mice exposed to heat with and without mechanisms engaged. Performance occurs in Los Angeles, California. The award period runs through August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $123.9k | 8/21/26 |