This federal Project Grant award of $737,732.00, awarded on July 23, 2024 by the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research), supports research on the causes and consequences of DNA replication stress in the mammalian preimplantation embryo. The research aims to identify the causes of DNA replication stress, characterize replication timing during preimplantation development, and correlate replication timing...
The federal Project Grant award R01HD113747, funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to elucidate the mechanisms that establish and balance stem cell fate in the male germline. The $1,216,126 award to Washington State University, spanning August 2024 to April 2029, aims to functionally evaluate the roles of RUNX1 and RUNX3 transcription factors in...
This $171,073 Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), will support research investigating the relationship between genome mutagenesis, fertility, and health in fertile and infertile men. The project aims to comprehensively characterize the mutational landscape in the sperm of fertile and infertile men to illuminate key biological and mutagenic...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) totaling $380,546 supports research to define how post-transcriptional regulation shapes gene expression programs that support the function of spermatogonial stem and progenitor cells in the mouse model. The key research objectives are: 1) to test the hypothesis that the RNA-binding protein DAZL enhances retinoic acid-mediated changes in...
This Project Grant award of $380,495, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the mechanisms and factors that promote aberrant DNA repair at meiotic double-strand breaks in the germline, which can lead to the formation of de novo structural variants. The research program, conducted by the Regents of the University of Michigan, aims to better understand how...
The federal Project Grant award for "The Mechanisms of MEIG1 Complex in Mammalian Spermiogenesis and Fertilization" (Federal Grant Award ID: R01HD114311) is provided by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $658,633 award, with a project period from August 2024 to April 2029, supports research to investigate the role of the MEIG1 protein complex in sperm formation and...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $160,877 to the University of Wisconsin-Madison for research on the role of histone demethylases in primordial germ cell specification during mouse embryonic development. The project aims to elucidate how the removal of repressive epigenetic modifications, such as H3K9me2, is coordinated with...
This $169,500 Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research by New York University (NYU) School of Medicine to characterize soma-germline interactions during adult spermatogenesis. The research aims to determine how a secreted, conserved, immunoglobulin (Ig) domain protein maintains the blood-testis barrier in somatic support cells of the...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 - Child Health and Human Development Extramural Research program provides $192,056 to the Magee-Womens Research Institute and Foundation to conduct research on adeno-associated virus (AAV) gene therapy to restore fertility in mammalian Sertoli cell dysfunction models. The project aims to demonstrate the feasibility and safety of in vivo Sertoli cell gene therapy using...
The National Institute of Child Health and Human Development (NICHD) awarded a Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Whitehead Institute for Biomedical Research. The $271,728 grant, awarded on September 15, 2024, will support research to uncover the molecular mechanisms that initiate and maintain germ cell identity. The research aims to (a) discover the dynamics of germline gene activation during embryogenesis, (b) identify...
This federal Project Grant award, valued at $107,458 and provided by the National Institute of Child Health and Human Development (NICHD) under CFDA Program 93.865 (Child Health and Human Development Extramural Research), supports research at Duke University to investigate DNA double-strand break repair mechanisms in fetal male germ cells. The overall objective is to determine how male germ cells respond to and repair DNA double-strand breaks, and to elucidate the importance of this process for the development of spermatogonial stem cells. The research will employ single-cell transcriptomics, genetic models, and a novel in vivo CRISPR-Cas9 assay to define the DNA repair pathways utilized by male germ cells and assess the implications of repair defects on spermatogonial stem cell development. Successful completion of this award, which runs from May 1, 2025 to April 30, 2027, will provide the foundation for the awardee to transition into an independent research career focused on advancing knowledge to improve reproductive health.