Project Grant K99GM166867
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded Northwestern University $924,556 on September 15, 2025, through the Biomedical Research and Research Training program (CFDA 93.859) to conduct mechanistic studies of ATP-binding cassette (ABC) importers in pathogenic bacteria. The funded research combines biochemical, biophysical, and structural biology experiments to understand how ABC transporter...
- The National Institute of General Medical Sciences awarded The University of Chicago $149,650 on July 16, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop methods for predicting, designing, and controlling microbiome metabolism across human and environmental contexts. The research combines microbial physiology with quantitative statistical and modeling approaches to address gaps in understanding microbial traits—the metabolic capabilities and...
- The National Institute of General Medical Sciences awarded The University of Chicago $226,884 on January 18, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop multiscale computational simulations investigating actin filament branch formation and aging dynamics. The recipient will model the role of ATP hydrolysis and nucleotide state in actin-related protein (ARP) 2/3 complex subunits during branch aging and dissociation. The work focuses on mechanistic...
- The National Institute of General Medical Sciences awarded The University of Chicago $602,095 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the structure and function of molecular machines involved in protein and RNA modifications. Over the five-year performance period ending June 30, 2031, the laboratory will conduct integrated structural and biochemical studies of three interconnected systems: the ubiquitin-proteasome pathway...
- The National Institute of General Medical Sciences awarded the University of Chicago $451,000 in project grant funding on April 1, 2026, to define the regulatory control of desiccation tolerance in Acinetobacter baumannii, an opportunistic bacterial pathogen that persists on contaminated surfaces through extreme water-loss tolerance. The research investigates the regulatory mechanisms and signal transduction pathways that enable A. baumannii to sense and respond to desiccation stress, focusing...
- The National Institute of General Medical Sciences awarded The University of Chicago $150,104 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular mechanisms underlying the repeated functional evolution of bioluminescent proteins derived from haloalkane dehalogenases. The research examines how a new catalytic mechanism—monooxygenase-catalyzed light production—repeatedly evolved in distantly related taxa by recruiting...
- The National Institute of General Medical Sciences awarded The University of Chicago $487,525 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop evolution-based understanding and design of proteins through generative AI models and experimental validation. The work centers on deducing design principles by which high-performance, robustness, and adaptability are realized in protein evolution. The recipient will develop a generative model enabling...
- Federal Project Grant Award Summary The University of Chicago received a $1,970,835 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on September 15, 2025, with a completion date of August 31, 2029. This award funds fundamental biomedical research focused on multiscale computational simulation of key biomolecular processes within cells, specifically addressing biological membranes,...
- The National Institute of General Medical Sciences awarded The University of Chicago $451,000 on March 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop statistical methods linking genetic variants to regulatory landscapes and disease mechanisms. The award funds research to move beyond cis gene regulation toward trans regulation of genes and proteins and genetic regulation of the epigenome. Specific deliverables include comprehensively mapping...
- The National Institute of General Medical Sciences awarded The University of Chicago $451,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to advance miniature CRISPR systems through directed evolution and machine learning-driven protein engineering. The award supports three integrated projects: Project 1 combines directed evolution and machine learning to reprogram the target-adjacent motif recognition of IscB, a miniature CRISPR nuclease,...
The National Institute of General Medical Sciences awarded The University of Chicago $125,820 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to integrate evolutionary history and biophysics toward combating antibiotic resistance through study of bacterial Na+/H+ antiporters and related proton-coupled transporters. The research targets Na+/H+ antiporters, a diverse family of membrane proteins essential to bacterial stress resistance and virulence during infection. Many pathogenic bacterial strains rely on the oligomerization of these antiporters to survive hostile conditions such as low pH or high salinity. The project will combine evolutionary and biophysical principles to identify key mutations and evolved features that enable these transporters to function across diverse bacterial species, with the goal of developing new antimicrobial compounds. The work recognizes that lipid microenvironment changes influence antiporter channel activity, requiring context-aware understanding of how these proteins function in cellular membranes. Work is performed in Chicago, Illinois. The award period runs from August 1, 2026, through July 31, 2028. This is a project grant, the standard NIH mechanism for investigator-initiated biomedical research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.8k | 7/30/26 |