Project Grant K99GM166692
- The National Institute of General Medical Sciences awarded The Trustees of Princeton University $451,000 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) for discovery and engineering of enzymes that modify amino acids and peptides for use as synthetic tools in biomedical research. The research develops methods to discover, characterize, and engineer enzymes and metabolic pathways involved in amino acid and peptide modification. The work focuses on...
- The National Institute of General Medical Sciences awarded The Trustees of Princeton University $2,993,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop chemistry-driven tools for studying protein function through intein-mediated protein splicing. The research focuses on three major areas: exploitation and extension of protein transposition technology to replace designated internal regions of folded proteins or protein complexes with...
- The National Institute of General Medical Sciences awarded The Trustees of Princeton University $165,366 on May 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop photoenzymes for selective chemical synthesis. The research will engineer naturally occurring dark enzymes to function as photoenzymes—biological catalysts that use photonic energy to drive chemical reactions—to address selectivity challenges in radical organic chemistry. The work includes...
- The National Institute of General Medical Sciences, part of the National Institutes of Health within the Department of Health and Human Services, awarded $227,652 to The Trustees of Princeton University on June 26, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop stereoselective photoenzymatic methods for oxygen- and nitrogen-centered radical transformations mediated by pyridoxal 5'-phosphate cofactors. The project will leverage pyridoxal...
- The National Institute of General Medical Sciences (NIGMS) awarded $369,000 to Princeton University on June 1, 2026, under CFDA 93.859 (Biomedical Research and Research Training) to support optogenetic tools and biosensor development for studying intracellular signaling and cellular decision-making. The Toettcher Laboratory at Princeton will develop cutting-edge optogenetic tools and biosensors to probe and manipulate cells' internal states over the five-year performance period ending May 31,...
- The National Institute of General Medical Sciences awarded The Trustees of Princeton University $2,227,666 on August 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support chemical approaches to investigating post-transcriptional RNA regulation through the Kleiner Group at Princeton. The funded research applies chemical biology, proximity labeling, and mass spectrometry methods to map and characterize the spatial distribution and subcellular dynamics of...
- The National Institute of General Medical Sciences awarded Yale University $420,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop next-generation proximity labeling enzymes, chemistries, and probes for expanded proteomic and lipidomic analysis. The research addresses limitations in current proximity labeling applications, which create localized reactive intermediates to tag nearby proteins in their native cellular environment. Existing...
- The National Institute of General Medical Sciences awarded The Trustees of Princeton University $137,484 on February 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to discover and characterize cryptic bacterial metabolites from algal and plant root microbiomes using ecology-guided high-throughput elicitor screening. The recipient will investigate bacterial respiratory stress as a metabolic switch for cryptic metabolite production, focusing on ceramide lipids...
- The National Institute of Biomedical Imaging and Bioengineering awarded Emory University $217,443 on August 5, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop class-selective chemical probes that distinguish reactive aldehyde signaling in living systems. The research will create a sensing platform capable of discriminating four mechanistically distinct classes of reactive aldehydes—monoaldehydes, α-dicarbonyls,...
- The National Institute of General Medical Sciences awarded The Trustees of Princeton University $225,564 on March 6, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop light-driven deracemization methods for atropisomers using chiral photocatalysts. The research aims to create a broadly applicable strategy to convert readily available racemate compounds into enantiopure atropisomers through photocatalytic processes, enabling facile access to structural...
The National Institute of General Medical Sciences awarded Princeton University $125,000 on August 6, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop activity-based probes for detecting and characterizing reactive oxygen species and aldehydes in living systems. The research focuses on developing chemoproteomic methods and activity-based probes to identify molecular targets of reactive oxygen species and aldehydes across the proteome, with emphasis on multiplexed detection and quantification of aldehyde species in genetic models with compromised aldehyde metabolism. Specific aims include applying activity-based protein profiling methods to identify targets derived from tryptophan, lysine, and arginine across whole proteomes and developing probes to enable multiplexed detection of biological aldehyde flux. The work addresses how reactive metabolites contribute to both health and disease, given their roles in carcinogenesis and their connection to chronic liver disorders, cancer, diabetes, cardiovascular disease, and neurodegeneration. The award is classified as a Project Grant. Performance occurs at Princeton, New Jersey, with a period of performance through July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.0k | 8/6/26 |