Project Grant K99GM159067
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Princeton University $294,060 under the Biomedical Research and Research Training program (CFDA 93.859) for a five-year project (September 1, 2025 – August 31, 2030) investigating biophysical principles of cellular organization. The project addresses emergent collective behavior in living systems across two distinct biological scales: bacterial quorum sensing in natural environments and phase...
- Federal Grant Award Summary Princeton University received a $1,968,575 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded September 15, 2025, with completion targeted for August 31, 2029. The award supports the development of computational approaches and machine learning methods to elucidate proteomes and protein interaction networks. The research initiative will advance understanding of...
- Federal Grant Award Summary Princeton University received a $451,000 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on July 23, 2025, with a completion date of June 30, 2027. The award funds research to identify novel antimicrobial targets in gram-negative bacterial pathogens through chemical synthetic lethality—a methodology that exploits the synergistic lethal effects of...
- Federal Grant Award Summary Princeton University received an $880,000 Project Grant from the National Science Foundation's Division of Molecular and Cellular Biosciences (CFDA 47.074 – Biological Sciences program) awarded on September 15, 2025, with a completion date of August 31, 2028. The grant funds research into synthetic symbiotes and opine-mediated plant-microbe interactions, focusing on improving the colonization and persistence of beneficial bacteria in agricultural settings. The primary...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Princeton University $180,998 through the Biomedical Research and Research Training program (CFDA 93.859) on May 1, 2025, to support investigator-initiated research on the role of the adaptor protein enkurin in left-right (LR) patterning. This project grant, which runs through December 31, 2027, funds fundamental biomedical research aimed at understanding the molecular mechanisms underlying...
- Federal Project Grant Award Summary The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences has awarded Princeton University $1,000,000 through the Biological Sciences program (CFDA 47.074) to conduct a four-year research project on quorum sensing across bacterial scales and domains. Commencing August 1, 2025, and concluding July 31, 2029, this project will investigate bacterial cell-to-cell communication mechanisms and their applications in controlling pathogenic...
- Federal Grant Award Summary Rutgers The State University of New Jersey received a $431,750 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 12, 2025, with a completion date of May 31, 2030. The award supports fundamental research investigating how ecological interactions affect mutant fitness and evolution in microbial communities. The research aims to develop predictive...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Washington University a Project Grant totaling $326,550 under the Biomedical Research and Research Training program (CFDA 93.859) beginning September 1, 2025, and concluding August 31, 2030. This five-year award supports advanced ecological theory research focused on understanding and predicting microbial ecosystem function and dynamics. The research leverages a novel theoretical...
- Federal Grant Award Summary Indiana University received a $446,435 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective September 4, 2025, with a completion date of June 30, 2029. The award supports fundamental research investigating the mechanisms of pterin-dependent regulation in proteobacterial systems, specifically examining how excreted metabolites called pterins control...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded The Washington University a Project Grant of $416,050 on August 5, 2025, under the Biomedical Research and Research Training program (CFDA 93.859) to support fundamental research on metabolic and regulatory control of antibiotic production in filamentous actinobacteria. The research will extend through May 31, 2030, and focuses on understanding why the majority of actinobacterial biosynthetic...
The National Institute of General Medical Sciences (NIGMS) awarded Princeton University $137,484 under the Biomedical Research and Research Training program (CFDA 93.859) for a two-year project period (February 1, 2026 – January 31, 2028). The award supports research titled "Leveraging Ecological Interactions to Unearth Cryptic Metabolites and Regulatory Pathways from Algal and Plant Microbiomes." The project will develop and apply an ecology-guided high-throughput elicitor screening (ECO-HITES) platform to discover previously unidentified bacterial natural products and their activation mechanisms. Specifically, the research will investigate how respiratory stress functions as a metabolic switch for cryptic metabolite production in bacteria, with initial focus on ceramide biosynthesis in model organisms and subsequent application to plant root microbiomes. The deliverables include mechanistic characterization of how environmental molecules trigger dormant metabolic pathways in bacterial microbiomes, identification of novel secondary metabolites beyond ceramides, and evaluation of whether respiratory modulation represents a conserved mechanism across bacterial species. This fundamental research advances the understanding of bacterial natural product biosynthesis, which has potential applications for pharmaceutical and industrial discovery. The work will be conducted at Princeton University's Office of Research and Project Administration in Princeton, New Jersey.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $137.5k | 1/28/26 |