Project Grant K99GM164773
- The National Institute of General Medical Sciences awarded the University of Pittsburgh $414,677 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop novel peptide nucleic acid (PNA) approaches for targeting mitochondrial DNA heteroplasmy in primary mitochondrial diseases. The funded research addresses the lack of approved methods to selectively modify or repair pathogenic mitochondrial DNA variants. The project integrates three complementary...
- The National Institute of General Medical Sciences awarded Yale University $125,000 on February 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the influences of developmental metabolic flux on physicochemical properties of the nucleus. The research focuses on how metabolic changes during cell differentiation alter mechanical properties of the nuclear envelope, with particular attention to polyamine biosynthesis. The investigator will test...
- The National Institute of General Medical Sciences awarded the University of California, San Diego $440,000 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to conduct research on membrane-protein interactions that control mitochondrial shape and function. The research develops multiscale biophysical tools and computer simulations to integrate molecular details into models of large-scale membrane bending in mitochondria. The work addresses two problem...
- The National Institute of General Medical Sciences, part of the National Institutes of Health within the Department of Health and Human Services, awarded The University of Texas Southwestern Medical Center $488,525 on July 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859), a Project Grant (R35GM162011). The award funds evolution-guided studies of mitochondrial activities and the host response to infectious agents. The research characterizes newly identified...
- The National Institute of General Medical Sciences awarded Massachusetts Institute of Technology $127,567 on September 3, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate mechanisms of nuclease-based bacterial immunity systems. The research, carried out in Cambridge, Massachusetts, through August 31, 2028, combines genetic and molecular biology approaches with training in biochemistry, structural biology, and computational methods to dissect how...
- The National Institute of General Medical Sciences awarded University of Texas at Austin $434,480 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to elucidate the mechanisms of mitochondrial DNA heteroplasmy quality control. The project investigates how mitochondrial genomes maintain fidelity when both wild-type and mutant mtDNA coexist (heteroplasmy), and how tissue-specific thresholds govern mitochondrial function. The research leverages...
- The National Institute of General Medical Sciences awarded Weill Medical College of Cornell University $118,751 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate the molecular basis and physiological impact of mRNA 5' nucleotide expansion. The award funds research defining how mRNA 5' expansion—a previously unrecognized transcriptional phenomenon in which additional A and U nucleotides are incorporated near transcript 5' ends in a...
- The National Institute of General Medical Sciences awarded The Trustees of Columbia University in the City of New York $125,000 on April 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859, assistance type Project Grant K99GM159103). The award funds research into the molecular causes and physiological and behavioral consequences of extreme glucocorticoid levels in Peromyscus mice species. The investigator will identify biochemical causes and physiological...
- The National Institute of General Medical Sciences, part of the Department of Health and Human Services National Institutes of Health, awarded New York University $421,737 on March 10, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to develop data-driven, predictive biophysical models of molecular mechanisms underlying cellular quiescence in microorganisms. The research focuses on quantitative relations between physiological traits and molecular processes in...
- The National Institute of General Medical Sciences awarded Thomas Jefferson University $392,500 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support research on autophagy of mitochondria containing mitochondrial DNA (AUMID). The project investigates the molecular mechanisms that regulate and drive selective autophagy of mitochondria enriched for mtDNA in a cell-type-specific manner, distinct from damage-induced mitophagy. The research will...
The National Institute of General Medical Sciences awarded New York University $125,000 on September 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to support a K99/R00 project investigating mitonuclear regulation in Caenorhabditis elegans. The research aims to determine how interactions between mitochondrial and nuclear genomes regulate gene expression and stress responses across tissues. Using natural mitochondrial variation in C. elegans combined with genome engineering and phenotypic analysis, the project will examine how mitochondrial haplotypes shape transcriptional and translational responses to stress in tissue- and environment-dependent ways. The study addresses the regulatory mechanisms and evolutionary dynamics of mitonuclear coordination, which remains poorly understood despite clinical relevance to mitochondrial syndromes, neurodegenerative disorders, and metabolic diseases. Performance occurs at New York University in New York, New York, with a period of performance from September 1, 2026, through August 31, 2028. The award is structured as a K99/R00 mentored research-to-independent research transition grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.0k | 8/14/26 |