Project Grant K99EY038313
- The National Eye Institute awarded the University of California, Los Angeles $244,150 on April 15, 2026, under the Vision Research program (CFDA 93.867) to support a project grant investigating molecular gradients underlying wiring plasticity in the visual cortex. The research combines single-cell transcriptomics, epigenomics, connectomics, and computational analysis to link genes, cell types, regulatory networks, and circuit structure in layers 2 and 3 (L2/3) glutamatergic neurons in the...
- The National Eye Institute awarded the University of California, Berkeley $143,031 on December 4, 2025, under the Vision Research program (CFDA 93.867) to computationally model the role of spatial phase in the selectivity and invariance of responses in primary visual cortex (V1) and secondary visual cortex (V2) to intermediate-level features in natural images. The modeling-driven research will investigate how phase-related computations operate across V1 and V2 and generate testable predictions...
- The National Eye Institute awarded Yale University $494,972 on May 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the neural dynamics of schema-based associative learning using magnetoencephalography (MEG). The research tests the representational coherence hypothesis by examining how prior knowledge—specifically the semantic congruency between objects and scenes—enhances learning and memory. Yale will conduct two studies using complementary MEG technologies: SQUID, an...
- The National Eye Institute, an office of the National Institutes of Health under the Department of Health and Human Services, awarded New York University $140,184 under the Vision Research program (CFDA 93.867) on July 1, 2026, to support research decoding the molecular logic of visual map formation in Drosophila. The award funds a career development and research project that investigates how spatial codes in developing photoreceptors guide topographic connectivity in downstream neural...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded The University of Chicago $929,806 on September 30, 2025, under the Vision Research program (CFDA 93.867). The award funds research into synaptic development of the retinogeniculate pathway—the neural circuit connecting the eyes to the brain—with investigation focused on how neurons form correct connections during childhood development and how visual experience shapes that...
- The National Eye Institute awarded the University of Wisconsin System $498,000 on September 15, 2025, under the Vision Research program (CFDA 93.867) to support research characterizing the neural signals that drive error-dependent motor learning in the cerebellar circuit during pursuit direction learning. The research aims to identify circuit-level principles of operation that underpin neural learning circuits more broadly by examining how synaptic plasticity at specific cerebellar synapses...
- The National Institutes of Health National Eye Institute awarded Yale University $132,030 on December 21, 2025, under the Vision Research program (CFDA 93.867) to study mechanisms of experience-dependent plasticity in mouse visual cortex. The recipient will combine in vivo two-photon imaging of neuronal activity and glutamatergic signaling with behavioral training and virally-induced genetic manipulation to monitor visually-evoked responses across adaptation under different experimental...
- The National Eye Institute awarded Massachusetts Institute of Technology $812,878 on August 1, 2026, under the Vision Research program (CFDA 93.867) to examine myelin plasticity in the visual system following extended visual deprivation. The project investigates whether myelin—the insulating layer around nerve fibers—undergoes activity-dependent modifications in response to late-onset visual experience in children. Traditionally, myelin changes have been understood as early developmental...
- The National Eye Institute awarded the University of California, Los Angeles $132,173 on May 1, 2026, under the Vision Research program (CFDA 93.867) to support research linking physiology, computation, and circuitry in primate visual cortex. The project funds development of experimental and analytical approaches to understand canonical computations—fundamental processing patterns underlying neural functions across hierarchical brain networks—by studying marmoset early visual areas V1 and V2....
- The National Eye Institute awarded The Schepens Eye Research Institute $858,394 on August 1, 2026, under the Vision Research program (CFDA 93.867) to develop multimodal foundation models for eye disease screening and prognosis. The research develops a vision-language foundation model trained on pairs of retinal images and clinical notes to enable downstream supervised models for detection and progression prediction of age-related macular degeneration, diabetic retinopathy, and glaucoma. The...
The National Eye Institute awarded Brandeis University $118,014 on September 1, 2026, under the Vision Research program (CFDA 93.867) to fund research characterizing learning-induced remodeling of cortical circuitry and computation during the critical period of visual system development. Dr. Bissen will investigate how prey capture learning—a complex, vision-dependent behavioral paradigm—remodels layer 5 circuitry in the visual cortex of critical period mice. Prior postdoctoral work demonstrated that this learning enhances visual function and profoundly rewires layer 5 circuitry in juvenile mice but not in adult hunters, suggesting critical period-specific mechanisms underlie the changes. The proposed research will examine the roles of genetically defined layer 5 pyramidal neuron subtypes and their associated circuitry during learning. Aim 1 will assess whether these subtypes play distinct roles during the critical period and will characterize their behavioral contributions to vision-dependent learning and underlying structural plasticity. Aim 2 will determine the impact of vision-dependent learning on neuronal computation in these neurons—specifically how they process and integrate sensory inputs. Performance occurs at Brandeis University in Waltham, Massachusetts. The period of performance runs from September 1, 2026, through August 31, 2028. This is a Project Grant, a non-renewable assistance type under the Vision Research program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $118.0k | 9/2/26 |