This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program provides $124,087 to the University of Louisville to conduct research on the link between heavy metal exposure, specifically cadmium, and the development of triple negative breast cancer (TNBC). The research aims to determine how cadmium exposure disrupts DNA double-strand break repair pathways, including the BRCA1 gene, to promote TNBC initiation and progression. The project will employ mass spectrometry, single-molecule imaging, and CRISPR-based techniques to elucidate the molecular mechanisms by which cadmium targets DNA repair proteins. Findings from this work are expected to provide critical insights into environmental factors contributing to TNBC disparities, particularly among young Black women. The award period runs from August 2024 through July 2026.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $6.6k | 8/27/24 | ||
| Not listed | $117.5k | 8/16/24 |