Project Grant K99DA066943
- The National Institute on Drug Abuse awarded The Johns Hopkins University $686,170 under the Drug Use and Addiction Research Programs (CFDA 93.279) on June 15, 2026, to develop and evaluate the Better Together intervention, an eight-session, age-appropriate substance use prevention program for adolescents ages eleven to thirteen exposed to household challenges including parental substance use, parental incarceration, and parental mental health issues, and negative neighborhood contexts including...
- The National Institute on Drug Abuse awarded The Johns Hopkins University $155,500 under the Drug Use and Addiction Research Programs (CFDA 93.279) on August 1, 2026, to develop and pilot the PROTECT-ED intervention, which addresses overdose and HIV prevention for individuals recently released from incarceration. The award funds research to refine and test an emergency department–based intervention designed to identify recently incarcerated patients and offer same-day medications for opioid...
- The National Institute on Drug Abuse awarded Johns Hopkins University $198,164 on October 17, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct research examining barriers to medications for opioid use disorder (MOUD) treatment for individuals transitioning from correctional facilities to community settings. The research employs a complex systems approach combining quantitative and qualitative methods. Specific aims include examining the structure and function...
- The National Institute on Drug Abuse awarded the University of California, San Diego $879,000 on March 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to develop and validate a novel episode-based paradigm for studying how family processes drive adolescent substance use. The project will collect real-time, real-world intensive longitudinal data on discrete parent and youth behaviors before and after episodes of substance use from 90 adolescents who use substances....
- The National Institute on Drug Abuse awarded $121,500 to the University of Kansas Center For Research Inc. on December 1, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279). The research investigates contextual factors influencing cannabis use and behavioral economic demand in naturalistic environments. The project employs ecological momentary assessment and behavioral economic purchase tasks to extend laboratory-based research into real-world settings. The study will conduct...
- The National Institute on Drug Abuse awarded The Johns Hopkins University $194,271 under Project Grant R21DA064845 on May 1, 2026, for exploratory research on rodent models of cannabis drug discrimination and self-administration to support medication development for cannabis use disorder. The recipient will develop and optimize rodent models using vaporized cannabis extract to establish reliable drug discrimination and self-administration procedures. Aim 1 applies drug discrimination...
- The National Institute on Drug Abuse awarded The Johns Hopkins University $466,363 on June 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to characterize allosteric crosstalk among opioid and endogenous neuromodulator receptors. The project uses cryo-electron microscopy to determine high-resolution structures of the mu-opioid receptor in active and inactive states bound to cannabinoids and neuropeptides including oxytocin. The work advances time-resolved cryo-EM...
- The National Institute on Drug Abuse awarded The Johns Hopkins University $631,094 on August 1, 2026, for research evaluating the neurocognitive, psychomimetic, and abuse-related effects of emerging psychoactive cannabinoids under the Drug Use and Addiction Research Programs (CFDA 93.279). The award funds a five-year project (August 1, 2026 through June 30, 2031) examining vaporized delta-8 tetrahydrocannabinol (D8-THC) and hexahydrocannabinol (HHC)—novel cannabinoids marketed as legal...
- The National Institute on Drug Abuse awarded the University of Oregon $731,194 on May 15, 2026, to conduct a micro-randomized trial testing mobile app-based just-in-time interventions for simultaneous alcohol and cannabis use among young adults under the Drug Use and Addiction Research Programs (CFDA 93.279). The research will develop and refine digital mindfulness-based and protective behavioral strategy intervention content, then deploy it through a randomized trial with daily-level...
- The National Institute on Drug Abuse awarded The Johns Hopkins University $698,861 on August 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct research characterizing mitochondrial regulation of inflammaging in immune cells and neurons and its effects on cognitive function among people with HIV who use substances. The research addresses cognitive impairment affecting 30 to 60 percent of people with HIV, with persons who inject drugs representing a particularly...
The National Institute on Drug Abuse awarded The Johns Hopkins University $138,201 for a Project Grant on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279). The award funds the HOPES2 SMS study, which develops and evaluates a culturally grounded, reinforcement learning-powered personalized just-in-time adaptive intervention delivered via SMS text message to prevent cannabis use escalation and suicidal ideation among urban American Indian and Alaska Native youth. The study uses community-based participatory research with three urban Indian health organizations in California to co-develop and pretest the intervention with urban AIAN youth and community members; evaluate intervention effects on proximal outcomes of mood, social connectedness, and SMS engagement through a micro-randomized trial with 240 participants; and assess impact on distal outcomes of cannabis use escalation, suicidal ideation severity, and behavioral healthcare service engagement using the RE-AIM framework. A contextual bandit reinforcement learning algorithm with a co-designed multi-objective reward function personalizes intervention delivery in real time. Performance occurs at Baltimore, Maryland, with a period of performance from August 1, 2026, through July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $138.2k | 7/25/26 |