Project Grant K99CA315599
- The National Cancer Institute awarded Dana-Farber Cancer Institute, Inc. $170,394 on July 1, 2026, under the Cancer Research Manpower program (CFDA 93.398) to support postdoctoral research training in cancer epigenetics. The award funds research examining polycomb repressive complexes and chromatin remodeling in neuroendocrine lineage carcinomas, particularly the transformation of conventional prostate adenocarcinoma into small-cell neuroendocrine prostate cancer. The investigator will conduct...
- The National Cancer Institute, a component of the Department of Health and Human Services National Institutes of Health, awarded Dana-Farber Cancer Institute, Inc. $134,919 under the Cancer Research Manpower program (CFDA 93.398) on June 11, 2026. The award funds structure-function and mechanistic studies of the protein-O-mannosyl transferase (POMT) complex in pediatric low-grade gliomas driven by the KIAA1549:BRAF fusion. The research aims to determine high-resolution structures of the POMT...
- The National Cancer Institute awarded Dana-Farber Cancer Institute, Inc. $230,388 on January 16, 2026, under the Cancer Research Manpower program (CFDA 93.398) to support basic research training in cancer biology and immunotherapy. The award funds research interrogating the role of interferon gamma (IFNG) in promoting metastasis and immune evasion of triple negative breast cancer. The research comprises two aims: elucidating IFNG's role in immune evasion during triple negative breast cancer...
- The National Cancer Institute awarded Dana-Farber Cancer Institute, Inc. $233,478 on September 1, 2026, under the Cancer Research Manpower program (CFDA 93.398) to characterize and target acquired resistance to menin-KMT2A inhibitors in acute myeloid leukemia. The award funds research profiling patient samples and patient-derived xenograft models to identify gain-of-function mutations in an oncogenic chromatin complex composed of menin, KMT2A, and PSIP1 proteins that confer resistance to menin...
- The National Cancer Institute awarded Dana-Farber Cancer Institute, Inc. $235,491 on May 1, 2026, under the Cancer Research Manpower program (CFDA 93.398) to support research training and career development in cancer research. The award funds investigation into high-count monoclonal B-cell lymphocytosis (HC-MBL) and its relationship to mosaic chromosomal alterations, particularly deletions in chromosome 13q and trisomy 12. The research will examine phenotypic consequences of HC-MBL across two...
- The National Cancer Institute, within the Department of Health and Human Services, awarded Dana-Farber Cancer Institute, Inc. $718,275 on July 1, 2026, under the Cancer Biology Research program (CFDA 93.396) to investigate context-specific pathway dependencies for nuclear envelope proteins in brain cancer. The research addresses how nuclear envelope-associated proteins perform distinct biochemical functions across different cellular contexts in central nervous system cancers. The project uses an...
- The National Cancer Institute awarded Dana-Farber Cancer Institute $110,190 on December 27, 2025, under the Cancer Research Manpower program (CFDA 93.398) to support research training in basic, clinical, and prevention research aligned with the National Cancer Program. The award funds investigation of mechanisms underlying neoantigen vaccine-induced epitope spreading in cancer immunotherapy. The research dissects how tumor neoantigen vaccines prime tumor-directed T cell responses and trigger...
- The National Cancer Institute awarded Dana-Farber Cancer Institute, Inc. $432,050 on August 17, 2026, under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop peptide-MHC pseudotyped retroviral vectors for in vivo gene delivery to antigen-specific T cells as a novel cancer immunotherapy approach. The work addresses a gap in current cancer immunotherapies by combining attributes of CAR-T cell therapies with tumor-infiltrating lymphocyte and immune checkpoint blockade...
- The National Cancer Institute, an office of the Department of Health and Human Services National Institutes of Health, awarded Dana-Farber Cancer Institute, Inc. $657,443 on September 1, 2026, under the Cancer Biology Research program (CFDA 93.396, Assistance Listing R01CA315392). The award funds structural and mechanistic studies of the RAS/RAF MAPKINASE pathway to achieve atomic-resolution understanding of how these proteins recognize and interact with one another and how these interactions...
- The National Cancer Institute awarded the University of Massachusetts Medical School $103,938 on January 12, 2026, under the Cancer Research Manpower program (CFDA 93.398) to support research identifying and targeting genetic determinants of immune suppression and immunotherapy failure in prostate cancer. The award funds doctoral research examining how interferon gamma (IFNG) signaling promotes tumor growth and immune suppression in neuroendocrine prostate cancer (NEPC) and drives resistance...
The National Cancer Institute awarded Dana-Farber Cancer Institute, Inc. $170,639 on August 24, 2026, under the Cancer Research Manpower program (CFDA 93.398) to support research on oxygen sensing, PTEN loss, and imaging biomarkers in prostate cancer radioligand therapy resistance. The award funds investigation of how hypoxia and HIF signaling regulate PSMA surface availability and how PTEN loss drives glucose and amino-acid transporter expression in prostate cancer cells. Aim 1 integrates spatial transcriptomics and proteomics to colocalize hypoxia signatures with PSMA localization in cell lines, organoids, and patient-derived tissues. Aim 2 uses isogenic models, live-cell trafficking assays, and glycan processing analyses to determine how PTEN loss alters microtubule and vesicular trafficking and PI3K/AKT/mTOR-dependent metabolism. Aim 3 tests whether HIF or LAT1 inhibition remodels tracer uptake, restores surface PSMA, and re-sensitizes tumors to 177Lu-PSMA therapy, with emphasis on standardized multi-tracer PET metrics and radiomics to improve patient selection and monitoring in PSMA-directed radioligand therapy. Work is performed in Boston, Massachusetts, with a period of performance through July 31, 2028. The Cancer Research Manpower program supports biomedical training opportunities for individuals pursuing careers in basic, clinical, and prevention research aligned with the National Cancer Program.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $170.6k | 8/24/26 |