Project Grant K99CA310811
- Federal Project Grant Award Summary The University of Pittsburgh received $141,566 in funding through the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) under a K99/R00 career development award, effective March 24, 2026 through February 28, 2028. This project grant supports research training and workforce development focused on understanding small guanosine triphosphatase (GTPase) proteins, specifically RhoA, and their role in cancer pathogenesis. The research aims to...
- Federal Grant Award Summary The University of Pittsburgh received a $149,804 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398) awarded March 1, 2025, with completion scheduled for February 28, 2026. This award supports research investigating the impact of LAG3 (Lymphocyte Activation Gene 3) on CD8+ T cell motility and migration in the context of cancer immunotherapy. The research builds upon preliminary findings demonstrating that...
- Federal Project Grant Award Summary The University of Pittsburgh received a $164,190 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), awarded January 21, 2026, with completion targeted for July 31, 2029. This award funds research into metastatic breast cancer subclone tracking through an innovative integration of machine learning and comprehensive autopsy data. The project will deliver computational analysis of DNA structural...
- Federal Project Grant Award Summary The University of Pittsburgh received a $261,662 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), effective December 1, 2025, with completion scheduled for April 16, 2029. The award funds an integrated in silico and in vivo genetic screening research initiative designed to identify subtype-specific genetic dependencies in hepatocellular carcinoma (HCC). The project employs a hybrid computational...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the University of Pittsburgh a $214,726 Career Development Project Grant under the Cancer Research Manpower program (CFDA 93.398) effective July 17, 2026, with completion targeted for June 30, 2031. This award supports an investigator's career development in cancer immunology, specifically focusing on transforming growth factor beta (TGF-β) regulation of immune evasion and metastasis in Ewing sarcoma. The primary...
- Federal Grant Award Summary The University of Pittsburgh received a $408,829 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective September 1, 2025 through August 31, 2027. The award supports development of an integrative framework for surface protein imputation in spatial biology applications. The project will advance understanding of tumor microenvironments by creating machine learning approaches to predict surface protein...
- Federal Project Grant Award Summary The University of Pittsburgh received a $151,040 Project Grant award from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398) effective December 12, 2025, with completion targeted for November 30, 2027. This award supports biomedical training and research development focused on advancing cancer immunotherapy research. Specifically, the grant funds investigation into the relative and synergistic contributions of...
- Federal Grant Award Summary The University of Pittsburgh received a $638,771 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) effective June 1, 2026, through May 31, 2031. This five-year award funds fundamental research investigating non-canonical functions of the mitochondrial fission protein DRP1 (dynamin-related protein 1) in high-grade serous ovarian cancer (HGSOC). The research focuses on understanding how a DRP1 splice variant...
- The University of Pittsburgh received a $169,982 Project Grant award from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398), effective August 8, 2025, through April 30, 2031. The award funds the Program in Cancer Training and Education (PICTE), an intensive research and professional development initiative designed to prepare rising sophomores and juniors for careers in cancer research and oncology. PICTE will enroll ten high-performing undergraduate...
- Federal Grant Award Summary The University of Pittsburgh received a $658,492 Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), effective March 18, 2026 through February 28, 2031. This award supports the development of a novel targeted combinatorial therapeutic approach for advanced castration-resistant prostate cancer (ACRPC), including castration-resistant prostate cancer adenocarcinoma (CRPC-ADENO) and neuroendocrine...
The University of Pittsburgh received a $125,783 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398), awarded July 7, 2026, with completion targeted for June 30, 2028. The award funds the development and evaluation of RUCAS (Rural Cancer Survivorship), a personalized, place-based digital health intervention designed to promote physical activity adherence among cancer survivors in rural areas. This initiative addresses a documented health disparity wherein rural cancer survivors face 10% higher mortality rates than urban counterparts and are 31% more likely to be physically inactive despite evidence that increased physical activity reduces cancer-related mortality by 20-40%. The K99/R00 career development grant supports two phases of work. During the K99 phase, the research team will characterize demographic and geographic factors of rural cancer survivors interested in digital health interventions through cross-sectional surveys (Aim 1) and assess preferred intervention components via semi-structured interviews (Aim 2). The R00 phase will refine and optimize the RUCAS intervention using user feedback and usability data in preparation for a larger randomized controlled trial. The Cancer Research Manpower program supports biomedical training and workforce development for individuals pursuing careers in cancer research, with this award contributing to both intervention development and career advancement in cancer survivorship research.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.8k | 7/8/26 |