Project Grant R21CA294196
- The University of Pittsburgh received a $585,931 Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) on February 3, 2025. The grant will fund a comprehensive research framework to determine the molecular credentials and selection of cancer models, such as cell lines, patient-derived xenografts (PDX), and patient-derived organoids (PDO), to guide translational and clinical applications in breast cancer. The key objectives are: (1) identifying and...
- The University of Pittsburgh has been awarded a $151,920 federal Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396). The goal of the research project is to design tailored NMR strategies for investigating inhibitor-induced conformational changes in the Src family kinase HCK, which is implicated in the development of acute myeloid leukemia. The research will focus on using tryptophan residues and site-specific 19F detection as sensitive probes...
- This federal Project Grant award of $584,510.00, provided by the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), supports the development of advanced spatial transcriptomics and proteomics technologies for studying tumor microenvironments. The award enables the University of Colorado-Denver to implement new imaging techniques and computational approaches to enhance the capabilities of its Human Immune Monitoring Shared Resource (HIMSR). This will allow...
- The Project Grant award of $424,734 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports the development of a novel spatial proteomics approach to profile immune cell types and their locations within a tumor microenvironment. The University of Illinois, the awardee, aims to integrate 3D microscopy techniques with bottom-up proteomic assays to offer deep proteome profiles of specific immune cells at various subregions of a mouse tumor (Aims 1 and 2). The goal is...
- The University of Pittsburgh received a $180,632 Project Grant from the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) to conduct research on halting breast cancer metastasis. The project aims to discover and validate compounds that can block the engulfment of mesenchymal stem cells (MSCs) by breast cancer cells, as this process has been linked to increased tumor growth, metastasis, and chemotherapy resistance. Using microfluidic technology, the researchers will create a...
- This Project Grant award of $176,712.00, provided by the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) to the University of Pittsburgh, supports research on immunosurveillance mechanisms that eliminate pre-cancerous cells prior to the formation of malignancies. The primary objective is to investigate how tumor-derived heat shock proteins (HSPs) engage the CD91 receptor on antigen-presenting cells, leading to priming of T cell responses against emerging tumors. This research...
- This Project Grant, awarded by the National Cancer Institute (CFDA 93.398 Cancer Research Manpower program), provides $121,857 to the University of Pittsburgh to systematically investigate the impact of anti-cancer drugs on T cells within the tumor microenvironment. The award aims to identify novel drug combinations that can overcome resistance to immune checkpoint blockade therapies in cancer treatment. Specifically, the research will involve in silico screening of anti-cancer drugs for their...
- This federal Project Grant award of $224,582, provided by the National Science Foundation (NSF) under the Computer and Information Science and Engineering (CISE) Program (CFDA 47.070), supports the development of a computational framework that integrates knowledge-driven and data-driven artificial intelligence (AI) approaches to recommend effective immunotherapeutic cell designs for cancer treatment. The framework aims to enable transformative cancer immunotherapy treatment designs by leveraging...
- This federal Project Grant award of $437,250.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund a 5-year research project at the University of Pittsburgh focused on advanced computational approaches for integrating single-cell multi-omics data. The key objectives of this project are to: 1) Develop novel integration methods for combining single-cell RNA-seq, ATAC-seq, and cytometry data to...
- This federal Project Grant award of $237,007 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) funds the development of two complementary software tools to facilitate cancer dependency research. The first tool aims to enable biomedical researchers without advanced computational skills to predict and interpret cancer dependencies through an intuitive, web-based interface powered by large language models. The second tool will create a scalable, modular...
The University of Pittsburgh was awarded a $408,829 Project Grant from the National Cancer Institute (CFDA 93.396 Cancer Biology Research) to develop an "Integrative Framework for Surface Protein Imputation for Spatial Biology of Cancer". The goal of the project is to increase the utility of spatial transcriptomics datasets by imputing surface protein abundance through incorporating spatial and histological dependencies, and simultaneously learning the RNA-protein mapping relation from spatial CITE-seq data. This will enhance the understanding of tumor biology and cellular interactions within spatial domains, facilitate the discovery of biomarkers, and inform targeted therapeutic interventions. The project will run from September 1, 2025 to August 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $408.8k | 8/28/25 |