Project Grant K01CA297060

Award Date 8/1/25
Completion Date 7/31/30
Dollars Obligated $192K
Federal Grant Program
93.398
Assistance Type
Project Grant
Place of Performance
Minnesota, USA
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The federal Project Grant award K01CA297060 from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower program) provides $192,240 to The University of Texas MD Anderson Cancer Center to conduct research on the role of mosaic chromosomal alterations (MCAs) in the risk and prognosis of lymphoid malignancies. The key objectives are to:

  1. Evaluate the association between MCAs and risk of different lymphoid malignancy subtypes by analyzing data from 34,519 prevalent cases and 63,103 controls, and validating findings in 5,029 incident cases and over 500,000 controls.

  2. Determine the prognostic role of MCAs in lymphoid malignancies by examining outcomes in 10,353 patients, accounting for factors like therapy, known prognostic indicators, MCA loci, and ancestry.

  3. Elucidate the blood cell lineage of MCAs in 2,164 lymphoid malignancy patients by comparing MCA events from peripheral blood to chromosomal alterations in matched tumor tissue.

This research aims to provide a deeper understanding of the relationship between MCAs and lymphoid malignancy subtypes, generating critical preliminary data to support future work on mechanisms, therapeutic implications, and broader health outcomes related to MCAs.

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