Project Grant K99CA304369
- Federal Grant Award Summary Yale University received a $150,104 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), awarded January 16, 2026, with a completion date of August 31, 2028. This award supports research investigating the impact of aberrant 5-methylcytosine (M5C) messenger RNA (mRNA) modifications on translation initiation and cancer development. The research focuses on determining how dose-sensitive M5C modifications in...
- Federal Project Grant Award Summary Yale University received a $192,564 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), effective September 1, 2025 through August 31, 2028. The award supports the development of innovative dual-target Protease Targeted Chimera (PROTAC)-based protein degraders designed to overcome therapy resistance in metastatic castration-resistant prostate cancer (MCRPC). The research addresses lineage...
- Federal Grant Award Summary The National Cancer Institute awarded Yale University a $295,192 Project Grant under the Cancer Research Manpower program (CFDA 93.398) effective July 1, 2026 through June 30, 2031. This award supports Dr. Goran Micevic's career development as an independent investigator in basic and translational tumor immunology, epigenetics, and spatial transcriptomics. The research focuses on enhancing melanoma adoptive immunotherapy by identifying and epigenetically reprogramming...
- Federal Grant Award Summary Yale University received a $672,371 Project Grant award from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research Program (CFDA 93.394), effective September 1, 2025, through August 31, 2028. The grant funds development of ultra-sensitive mass spectrometry-based immunopeptidomics technology utilizing digital microfluidics to identify tumor-specific antigens (TSAs) for cancer immunotherapy applications. The project addresses current...
- Federal Grant Award Summary Yale University received a $147,486 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) awarded July 1, 2025, with a completion date of June 30, 2028. This research grant funds investigation into the role of glycosylated RNAs (glycoRNAs)—RNA molecules post-transcriptionally modified with sialylated-N glycans—in acute myeloid leukemia (AML). The project delivers scientific research outputs across three primary aims:...
- Federal Grant Award Summary Yale University received a $610,637 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), awarded April 1, 2026, with completion targeted for March 31, 2031. The grant funds bioengineering research to develop an optimized drug delivery platform utilizing bioadhesive and non-adhesive biodegradable nanoparticles for locoregional treatment of advanced melanoma. The research will engineer nanoparticles with selective...
- Federal Grant Award Summary The National Cancer Institute awarded Yale University a $478,532 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective September 1, 2025, through August 31, 2027. This research initiative will investigate the biological and clinical significance of spatial immune heterogeneity in non-small cell lung cancer (NSCLC), with particular focus on characterizing how the spatial distribution of tumor-infiltrating lymphocytes (TILs) and tertiary...
- Federal Grant Award Summary Yale University received a $607,690 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) awarded on May 6, 2026, with a completion date of April 30, 2031. The grant funds development of an magnetic resonance (MR)-based imaging platform for high-resolution simultaneous intracellular pH (PHI) and extracellular pH (PHE) imaging in glioblastoma multiforme (GBM), an aggressive and chemotherapy-resistant...
- Federal Grant Award Summary Dana-Farber Cancer Institute, Inc. received a $170,641 Project Grant from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398) for the period August 1, 2025 through July 31, 2027. The award supports research training and investigator development focused on advancing understanding of tumor-immune interactions in colorectal cancer through multimodal spatial profiling analysis. The project will utilize highly multiplexed...
- Federal Grant Award Summary Yale University received a $167,771 Project Grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395) awarded August 1, 2025, with completion targeted for July 31, 2027. The award supports research to elucidate the mechanisms of a novel human-specific immune checkpoint interaction between SIGLEC-7 and VSIG4 proteins. The research will utilize a humanized mouse platform (MISTRG6-A2) to develop in vivo models that investigate how...
Yale University received a $130,490 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398) awarded on June 1, 2026, with completion anticipated by May 31, 2028. This award supports biomedical training and research career development initiatives focused on cellular and molecular mechanisms of early-onset colorectal cancer (EOCRC). The project addresses a significant public health concern, as incidence rates of colorectal cancer in individuals under 50 years of age have increased steadily since 1990, contrasting with declining rates in late-onset cases. The funding supports research infrastructure development and investigator training aligned with the National Cancer Program's strategic priorities in cancer research. The Cancer Research Manpower program provides institutions with resources to develop research training infrastructure, mentor early-stage and established investigators, and strengthen the scientific workforce in oncology. Yale's award will facilitate integrated research and clinical training activities conducted at its New Haven, Connecticut facility, supporting participants' development toward productive, independent research careers in cancer biology and prevention research. The program emphasizes scientific merit, technical adequacy, and relevance to announced cancer research objectives, with all applications subject to competitive review by the National Cancer Advisory Board.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $130.5k | 5/12/26 |